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- Publisher Website: 10.1073/pnas.0637450100
- Scopus: eid_2-s2.0-0037447089
- PMID: 12644709
- WOS: WOS:000182306100074
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Article: mRNA of placental origin is readily detectable in maternal plasma
Title | mRNA of placental origin is readily detectable in maternal plasma |
---|---|
Authors | |
Issue Date | 2003 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 8, p. 4748-4753 How to Cite? |
Abstract | The discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific target that can be used for prenatal screening and monitoring in all pregnant women has not been reported. In addition, the origin of such circulating nucleic acid has remained unclear. Here we provide direct evidence that the placenta is an important source of fetal nucleic acid release into maternal plasma by demonstrating that mRNA transcripts from placenta-expressed genes are readily detectable in maternal plasma. The surprising stability of such placental mRNA species in maternal plasma and their rapid clearance after delivery demonstrate that such circulating mRNA molecules are practical markers for clinical use. The measurement of such plasma mRNA markers has provided a gender-independent approach for noninvasive prenatal gene expression profiling and has opened up numerous research and diagnostic possibilities. |
Persistent Identifier | http://hdl.handle.net/10722/172826 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, EKO | en_US |
dc.contributor.author | Tsui, NBY | en_US |
dc.contributor.author | Lau, TK | en_US |
dc.contributor.author | Leung, TN | en_US |
dc.contributor.author | Chiu, RWK | en_US |
dc.contributor.author | Panesar, NS | en_US |
dc.contributor.author | Lit, LCW | en_US |
dc.contributor.author | Chan, KW | en_US |
dc.contributor.author | Lo, YMD | en_US |
dc.date.accessioned | 2012-10-30T06:25:09Z | - |
dc.date.available | 2012-10-30T06:25:09Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Proceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 8, p. 4748-4753 | en_US |
dc.identifier.issn | 0027-8424 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172826 | - |
dc.description.abstract | The discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific target that can be used for prenatal screening and monitoring in all pregnant women has not been reported. In addition, the origin of such circulating nucleic acid has remained unclear. Here we provide direct evidence that the placenta is an important source of fetal nucleic acid release into maternal plasma by demonstrating that mRNA transcripts from placenta-expressed genes are readily detectable in maternal plasma. The surprising stability of such placental mRNA species in maternal plasma and their rapid clearance after delivery demonstrate that such circulating mRNA molecules are practical markers for clinical use. The measurement of such plasma mRNA markers has provided a gender-independent approach for noninvasive prenatal gene expression profiling and has opened up numerous research and diagnostic possibilities. | en_US |
dc.language | eng | en_US |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | en_US |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Biological Transport, Active | en_US |
dc.subject.mesh | Dna Primers - Genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetus - Metabolism | en_US |
dc.subject.mesh | Gene Expression Profiling | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Maternal-Fetal Exchange - Genetics | en_US |
dc.subject.mesh | Placenta - Metabolism | en_US |
dc.subject.mesh | Placental Lactogen - Genetics | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Rna Stability | en_US |
dc.subject.mesh | Rna, Messenger - Blood - Genetics - Metabolism | en_US |
dc.subject.mesh | Reverse Transcriptase Polymerase Chain Reaction | en_US |
dc.title | mRNA of placental origin is readily detectable in maternal plasma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ng, EKO: ngko@hku.hk | en_US |
dc.identifier.authority | Ng, EKO=rp01364 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1073/pnas.0637450100 | en_US |
dc.identifier.pmid | 12644709 | - |
dc.identifier.scopus | eid_2-s2.0-0037447089 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037447089&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 100 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 4748 | en_US |
dc.identifier.epage | 4753 | en_US |
dc.identifier.isi | WOS:000182306100074 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Ng, EKO=21135553700 | en_US |
dc.identifier.scopusauthorid | Tsui, NBY=6602401748 | en_US |
dc.identifier.scopusauthorid | Lau, TK=24491963900 | en_US |
dc.identifier.scopusauthorid | Leung, TN=7202110927 | en_US |
dc.identifier.scopusauthorid | Chiu, RWK=7103038413 | en_US |
dc.identifier.scopusauthorid | Panesar, NS=7005824593 | en_US |
dc.identifier.scopusauthorid | Lit, LCW=6602660237 | en_US |
dc.identifier.scopusauthorid | Chan, KW=36915718400 | en_US |
dc.identifier.scopusauthorid | Lo, YMD=7401935391 | en_US |
dc.identifier.issnl | 0027-8424 | - |