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- PMID: 17845530
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Article: Oncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways
Title | Oncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways |
---|---|
Authors | |
Keywords | Biomarkers Hepatocellular carcinoma Proteomics |
Issue Date | 2007 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 |
Citation | Liver International, 2007, v. 27 n. 8, p. 1021-1038 How to Cite? |
Abstract | Hepatocellular carcinoma (HCC) is a heterogeneous cancer with no promising treatment and remains one of the most prevailing and lethal malignancies in the world. Researchers in many biological areas now routinely identify and characterize protein markers by a mass spectrometry-based proteomic approach, a method that has been commonly used to discover diagnostic biomarkers for cancer detection. The proteomic research platforms span from the classical two-dimensional polyacrylamide gel electrophoresis (2-DE) to the latest Protein Chip or array technology, which are often integrated with the MALDI (matrix-assisted laser-desorption ionization), SELDI (surface-enhanced laser desorption/ionization) or tandem mass spectrometry (MS/MS). New advances on quantitative proteomic analysis (e.g. SILAC, ICAT, and ITRAQ) and multidimensional protein identification technology (MudPIT) have greatly enhanced the capability of proteomic methods to study the expressions, modifications and functions of protein markers. The present article reviews the latest proteomic development and discovery of biomarkers in HCC that may provide insights into the underlying mechanisms of hepatocarcinogenesis and the readiness of biomarkers for clinical uses. © 2007 Blackwell Munksgaard. |
Persistent Identifier | http://hdl.handle.net/10722/172948 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 2.087 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sun, S | en_US |
dc.contributor.author | Lee, NPY | en_US |
dc.contributor.author | Poon, RTP | en_US |
dc.contributor.author | Fan, ST | en_US |
dc.contributor.author | He, QY | en_US |
dc.contributor.author | Lau, GK | en_US |
dc.contributor.author | Luk, JM | en_US |
dc.date.accessioned | 2012-10-30T06:25:57Z | - |
dc.date.available | 2012-10-30T06:25:57Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Liver International, 2007, v. 27 n. 8, p. 1021-1038 | en_US |
dc.identifier.issn | 1478-3223 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172948 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is a heterogeneous cancer with no promising treatment and remains one of the most prevailing and lethal malignancies in the world. Researchers in many biological areas now routinely identify and characterize protein markers by a mass spectrometry-based proteomic approach, a method that has been commonly used to discover diagnostic biomarkers for cancer detection. The proteomic research platforms span from the classical two-dimensional polyacrylamide gel electrophoresis (2-DE) to the latest Protein Chip or array technology, which are often integrated with the MALDI (matrix-assisted laser-desorption ionization), SELDI (surface-enhanced laser desorption/ionization) or tandem mass spectrometry (MS/MS). New advances on quantitative proteomic analysis (e.g. SILAC, ICAT, and ITRAQ) and multidimensional protein identification technology (MudPIT) have greatly enhanced the capability of proteomic methods to study the expressions, modifications and functions of protein markers. The present article reviews the latest proteomic development and discovery of biomarkers in HCC that may provide insights into the underlying mechanisms of hepatocarcinogenesis and the readiness of biomarkers for clinical uses. © 2007 Blackwell Munksgaard. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 | en_US |
dc.relation.ispartof | Liver International | en_US |
dc.subject | Biomarkers | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject | Proteomics | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular - Blood - Chemistry - Diagnosis | en_US |
dc.subject.mesh | Electrophoresis, Gel, Two-Dimensional | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver Neoplasms - Blood - Chemistry - Diagnosis | en_US |
dc.subject.mesh | Neoplasm Proteins - Analysis - Blood | en_US |
dc.subject.mesh | Protein Array Analysis | en_US |
dc.subject.mesh | Proteomics - Methods - Trends | en_US |
dc.subject.mesh | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | en_US |
dc.subject.mesh | Tandem Mass Spectrometry | en_US |
dc.subject.mesh | Tumor Markers, Biological - Analysis - Blood | en_US |
dc.title | Oncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, NPY: nikkilee@hku.hk | en_US |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_US |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_US |
dc.identifier.authority | Lee, NPY=rp00263 | en_US |
dc.identifier.authority | Poon, RTP=rp00446 | en_US |
dc.identifier.authority | Fan, ST=rp00355 | en_US |
dc.identifier.authority | Luk, JM=rp00349 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1478-3231.2007.01533.x | en_US |
dc.identifier.pmid | 17845530 | - |
dc.identifier.scopus | eid_2-s2.0-34548640225 | en_US |
dc.identifier.hkuros | 137597 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548640225&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 1021 | en_US |
dc.identifier.epage | 1038 | en_US |
dc.identifier.isi | WOS:000249433200001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Sun, S=21740136100 | en_US |
dc.identifier.scopusauthorid | Lee, NPY=7402722690 | en_US |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_US |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_US |
dc.identifier.scopusauthorid | He, QY=34770287900 | en_US |
dc.identifier.scopusauthorid | Lau, GK=7102301257 | en_US |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_US |
dc.identifier.citeulike | 1641817 | - |
dc.identifier.issnl | 1478-3223 | - |