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- Publisher Website: 10.3109/07357907.2012.691192
- Scopus: eid_2-s2.0-84863974406
- PMID: 22624612
- WOS: WOS:000306421800002
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Article: Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10
Title | Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10 |
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Authors | |
Keywords | Curcumin Matrix Metallopepetidase 10 Migration Squamous Cell Carcinoma Tongue |
Issue Date | 2012 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp |
Citation | Cancer Investigation, 2012, v. 30 n. 7, p. 503-512 How to Cite? |
Abstract | Squamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion. Copyright © 2012 Informa Healthcare USA, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/173035 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.604 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsang, RKY | en_US |
dc.contributor.author | Tang, WWY | en_US |
dc.contributor.author | Gao, W | en_US |
dc.contributor.author | Ho, WK | en_US |
dc.contributor.author | Chan, JYW | en_US |
dc.contributor.author | Wei, WI | en_US |
dc.contributor.author | Wong, TS | en_US |
dc.date.accessioned | 2012-10-30T06:26:46Z | - |
dc.date.available | 2012-10-30T06:26:46Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Cancer Investigation, 2012, v. 30 n. 7, p. 503-512 | en_US |
dc.identifier.issn | 0735-7907 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173035 | - |
dc.description.abstract | Squamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion. Copyright © 2012 Informa Healthcare USA, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp | en_US |
dc.relation.ispartof | Cancer Investigation | en_US |
dc.subject | Curcumin | en_US |
dc.subject | Matrix Metallopepetidase 10 | en_US |
dc.subject | Migration | en_US |
dc.subject | Squamous Cell Carcinoma | en_US |
dc.subject | Tongue | en_US |
dc.title | Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, TS: thiansze@graduate.hku.hk | en_US |
dc.identifier.email | Tsang, RKY: rkytsang@hku.hk | - |
dc.identifier.email | Gao, W: weigao@graduate.hku.hk | - |
dc.identifier.email | Ho, WK: wkho@hkucc.hku.hk | - |
dc.identifier.email | Chan, JYW: jywchan1@hku.hk | - |
dc.identifier.email | Wei, WI: hrmswwi@hku.hk | - |
dc.identifier.authority | Wong, TS=rp00478 | en_US |
dc.identifier.authority | Tsang, RKY=rp01386 | - |
dc.identifier.authority | Wei, WI=rp00323 | - |
dc.identifier.authority | Chan, JYW=rp01314 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3109/07357907.2012.691192 | en_US |
dc.identifier.pmid | 22624612 | - |
dc.identifier.scopus | eid_2-s2.0-84863974406 | en_US |
dc.identifier.hkuros | 200588 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84863974406&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 503 | en_US |
dc.identifier.epage | 512 | en_US |
dc.identifier.eissn | 1532-4192 | - |
dc.identifier.isi | WOS:000306421800002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Tsang, RKY=55314801700 | en_US |
dc.identifier.scopusauthorid | Tang, WWY=36469039200 | en_US |
dc.identifier.scopusauthorid | Gao, W=55252457300 | en_US |
dc.identifier.scopusauthorid | Ho, WK=7402968844 | en_US |
dc.identifier.scopusauthorid | Chan, JYW=55270446700 | en_US |
dc.identifier.scopusauthorid | Wei, WI=55251021200 | en_US |
dc.identifier.scopusauthorid | Wong, TS=7403531328 | en_US |
dc.identifier.issnl | 0735-7907 | - |