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Article: First trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21

TitleFirst trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21
Authors
Spencer, KHeath, VFlack, NOng, CNicolaides, KH
KeywordsFirst trimester screening
Free β-hCG
PAPP-A
Trisomy 13
Trisomy 18
Turner's syndrome
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 8, p. 635-639 How to Cite?
DOI: http://dx.doi.org/10.1002/1097-0223(200008)20:8<635::AID-PD868>3.0.CO;2-U
AbstractTotal human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were measured in maternal serum at 10-14 weeks of gestation from 53 pregnancies affected by trisomy 18, 42 cases with trisomy 13, 46 with Turner's syndrome and 13 with other sex aneuploides. The only significant association was the finding of reduced levels of total hCG in cases of trisomy 18 and 13. The association of increased levels of AFP in cases of trisomy 18 with ventral wall defects and the slight increase in AFP in cases of sex chromosomal anomalies other than Turner's syndrome was found. AFP and total hCG are not likely to replace the markers free β-hCG and PAPP-A in first trimester screening for chromosomal anomalies. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173240
ISSN
0197-3851
2021 Impact Factor: 3.242
2020 SCImago Journal Rankings: 0.956
ISI Accession Number ID
WOS:000088688700005
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_US
dc.contributor.authorHeath, Ven_US
dc.contributor.authorFlack, Nen_US
dc.contributor.authorOng, Cen_US
dc.contributor.authorNicolaides, KHen_US
dc.date.accessioned2012-10-30T06:28:43Z-
dc.date.available2012-10-30T06:28:43Z-
dc.date.issued2000en_US
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 8, p. 635-639en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/173240-
dc.description.abstractTotal human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were measured in maternal serum at 10-14 weeks of gestation from 53 pregnancies affected by trisomy 18, 42 cases with trisomy 13, 46 with Turner's syndrome and 13 with other sex aneuploides. The only significant association was the finding of reduced levels of total hCG in cases of trisomy 18 and 13. The association of increased levels of AFP in cases of trisomy 18 with ventral wall defects and the slight increase in AFP in cases of sex chromosomal anomalies other than Turner's syndrome was found. AFP and total hCG are not likely to replace the markers free β-hCG and PAPP-A in first trimester screening for chromosomal anomalies. Copyright (C) 2000 John Wiley and Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subjectFirst trimester screening-
dc.subjectFree β-hCG-
dc.subjectPAPP-A-
dc.subjectTrisomy 13-
dc.subjectTrisomy 18-
dc.subjectTurner's syndrome-
dc.subject.meshAdulten_US
dc.subject.meshAneuploidyen_US
dc.subject.meshChorionic Gonadotropin - Blooden_US
dc.subject.meshChromosomes, Human, Pair 13en_US
dc.subject.meshChromosomes, Human, Pair 18en_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Analysisen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshSex Chromosome Aberrations - Diagnosis - Geneticsen_US
dc.subject.meshTrisomyen_US
dc.subject.meshTurner Syndrome - Diagnosis - Geneticsen_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleFirst trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21en_US
dc.typeArticleen_US
dc.identifier.emailOng, C:cytong@hkucc.hku.hken_US
dc.identifier.authorityOng, C=rp00482en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0223(200008)20:8<635::AID-PD868>3.0.CO;2-Uen_US
dc.identifier.pmid10951473-
dc.identifier.scopuseid_2-s2.0-0033880562en_US
dc.identifier.hkuros79014-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033880562&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue8en_US
dc.identifier.spage635en_US
dc.identifier.epage639en_US
dc.identifier.isiWOS:000088688700005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSpencer, K=7202053140en_US
dc.identifier.scopusauthoridHeath, V=7004279928en_US
dc.identifier.scopusauthoridFlack, N=6603487468en_US
dc.identifier.scopusauthoridOng, C=7401968192en_US
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_US
dc.identifier.issnl0197-3851-

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