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- Publisher Website: 10.1002/pd.53
- Scopus: eid_2-s2.0-0035020972
- PMID: 11288115
- WOS: WOS:000168324900005
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Article: Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies
Title | Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies |
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Authors | |
Keywords | Down syndrome Free β-hCG Inhibin PAPP-A Prenatal screening |
Issue Date | 2001 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 2001, v. 21 n. 4, p. 270-273 How to Cite? |
Abstract | Maternal serum total activin-A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10-14 weeks of gestation. In the trisomy 21 pregnancies total activin-A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein-A (PAPP-A) in this trisomy 21 series was 0.49 and for free β-hCG was 2.05. In the trisomy group there were significant positive associations between total activin-A and PAPP-A (0.6071) and free β-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21. Copyright © 2001 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/173252 |
ISSN | 2021 Impact Factor: 3.242 2020 SCImago Journal Rankings: 0.956 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Spencer, K | en_US |
dc.contributor.author | Liao, AW | en_US |
dc.contributor.author | Skentou, H | en_US |
dc.contributor.author | Ong, CYT | en_US |
dc.contributor.author | Nicolaides, KH | en_US |
dc.date.accessioned | 2012-10-30T06:28:49Z | - |
dc.date.available | 2012-10-30T06:28:49Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 2001, v. 21 n. 4, p. 270-273 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173252 | - |
dc.description.abstract | Maternal serum total activin-A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10-14 weeks of gestation. In the trisomy 21 pregnancies total activin-A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein-A (PAPP-A) in this trisomy 21 series was 0.49 and for free β-hCG was 2.05. In the trisomy group there were significant positive associations between total activin-A and PAPP-A (0.6071) and free β-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21. Copyright © 2001 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | Down syndrome | - |
dc.subject | Free β-hCG | - |
dc.subject | Inhibin | - |
dc.subject | PAPP-A | - |
dc.subject | Prenatal screening | - |
dc.subject.mesh | Activins | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Chorionic Gonadotropin, Beta Subunit, Human - Blood | en_US |
dc.subject.mesh | Down Syndrome - Blood | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inhibins - Blood | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy-Associated Plasma Protein-A - Analysis | en_US |
dc.subject.mesh | Reference Values | en_US |
dc.title | Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ong, CYT:cytong@hkucc.hku.hk | en_US |
dc.identifier.authority | Ong, CYT=rp00482 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/pd.53 | en_US |
dc.identifier.pmid | 11288115 | - |
dc.identifier.scopus | eid_2-s2.0-0035020972 | en_US |
dc.identifier.hkuros | 78800 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035020972&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 270 | en_US |
dc.identifier.epage | 273 | en_US |
dc.identifier.isi | WOS:000168324900005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Spencer, K=7202053140 | en_US |
dc.identifier.scopusauthorid | Liao, AW=7006509060 | en_US |
dc.identifier.scopusauthorid | Skentou, H=23107786000 | en_US |
dc.identifier.scopusauthorid | Ong, CYT=7401968192 | en_US |
dc.identifier.scopusauthorid | Nicolaides, KH=7203078780 | en_US |
dc.identifier.issnl | 0197-3851 | - |