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- Publisher Website: 10.1093/humupd/8.3.255
- Scopus: eid_2-s2.0-0036562354
- PMID: 12078836
- WOS: WOS:000176189500005
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Article: New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome
Title | New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome |
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Authors | |
Keywords | CFTR Chlamydial infection Hydrosalpinx IVF |
Issue Date | 2002 |
Publisher | Oxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.org |
Citation | Human Reproduction Update, 2002, v. 8 n. 3, p. 255-264 How to Cite? |
Abstract | The adverse effects of hydrosalpinx on the outcome of IVF have been well documented; however, the causes for impaired implantation in patients with hydrosalpinx are poorly understood. Hydrosalpinx fluid has been shown to be toxic to mouse embryos but not human embryos, and this has become a topic of intense debate. An understanding of the mechanisms underlying hydrosalpinx formation following pelvic inflammatory disease appears to be essential in elucidating the causes for reduced implantation in hydrosalpinx patients and providing more rational treatments. This review discusses the mechanisms underlying hydrosalpinx formation and its adverse effect on IVF outcome, with new insights into possible involvement of Fallopian tube epithelial transporters and ion channels, particularly the cystic fibrosis transmembrane conductance regulator (CFTR). Possible links between Chlamydia trachomatis in pelvic inflammatory disease and the subsequent CFTR-mediated events in hydrosalpinx formation leading to infertility in hydrosalpinx are proposed. The causes of reduced implantation, particularly in patients with visible hydrosalpinges shown on ultrasound scanning, are re-examined in light of these possible mechanisms. |
Persistent Identifier | http://hdl.handle.net/10722/173262 |
ISSN | 2023 Impact Factor: 14.8 2023 SCImago Journal Rankings: 4.074 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ajonuma, LC | en_HK |
dc.contributor.author | Ng, EHY | en_HK |
dc.contributor.author | Chan, HC | en_HK |
dc.date.accessioned | 2012-10-30T06:28:52Z | - |
dc.date.available | 2012-10-30T06:28:52Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Human Reproduction Update, 2002, v. 8 n. 3, p. 255-264 | en_HK |
dc.identifier.issn | 1355-4786 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/173262 | - |
dc.description.abstract | The adverse effects of hydrosalpinx on the outcome of IVF have been well documented; however, the causes for impaired implantation in patients with hydrosalpinx are poorly understood. Hydrosalpinx fluid has been shown to be toxic to mouse embryos but not human embryos, and this has become a topic of intense debate. An understanding of the mechanisms underlying hydrosalpinx formation following pelvic inflammatory disease appears to be essential in elucidating the causes for reduced implantation in hydrosalpinx patients and providing more rational treatments. This review discusses the mechanisms underlying hydrosalpinx formation and its adverse effect on IVF outcome, with new insights into possible involvement of Fallopian tube epithelial transporters and ion channels, particularly the cystic fibrosis transmembrane conductance regulator (CFTR). Possible links between Chlamydia trachomatis in pelvic inflammatory disease and the subsequent CFTR-mediated events in hydrosalpinx formation leading to infertility in hydrosalpinx are proposed. The causes of reduced implantation, particularly in patients with visible hydrosalpinges shown on ultrasound scanning, are re-examined in light of these possible mechanisms. | en_HK |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.org | en_HK |
dc.relation.ispartof | Human Reproduction Update | en_HK |
dc.subject | CFTR | en_HK |
dc.subject | Chlamydial infection | en_HK |
dc.subject | Hydrosalpinx | en_HK |
dc.subject | IVF | en_HK |
dc.subject.mesh | Chlamydia Infections - Complications - Physiopathology | en_US |
dc.subject.mesh | Fallopian Tube Diseases - Physiopathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fertilization In Vitro - Adverse Effects - Methods | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Outcome | en_US |
dc.title | New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ajonuma, LC: louisca@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, EHY: nghye@hku.hk | en_HK |
dc.identifier.authority | Ajonuma, LC=rp00051 | en_HK |
dc.identifier.authority | Ng, EHY=rp00426 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/humupd/8.3.255 | en_HK |
dc.identifier.pmid | 12078836 | - |
dc.identifier.scopus | eid_2-s2.0-0036562354 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036562354&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 8 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 255 | en_HK |
dc.identifier.epage | 264 | en_HK |
dc.identifier.isi | WOS:000176189500005 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Ajonuma, LC=6602292557 | en_HK |
dc.identifier.scopusauthorid | Ng, EHY=35238184300 | en_HK |
dc.identifier.scopusauthorid | Chan, HC=7403402737 | en_HK |
dc.identifier.issnl | 1355-4786 | - |