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Article: Early detection of persistent trophoblastic tumour by serum human chorionic gonadotrophin monitoring after molar pregnancy
Title | Early detection of persistent trophoblastic tumour by serum human chorionic gonadotrophin monitoring after molar pregnancy |
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Authors | |
Keywords | Molar pregnancy Persistent trophoblastic tumour (PIT) Serum human chorionic gonadotrophin (hCG) monitoring |
Issue Date | 1999 |
Publisher | Chinese Medical Association. The Journal's web site is located at http://www.cmj.org/ |
Citation | Chinese Medical Journal, 1999, v. 112 n. 3, p. 260-263 How to Cite? |
Abstract | Objective: To study the outcome of a multi-centred post-molar pregnancy serum human chorionic gonadotrophin (hCG) surveillance programme. Methods: Patients recruited into the multi-centred post-molar serum hCG surveillance programme between 1988 and 1996 were studied. The clinical data were obtained from medical records and computer database. Results: There were 616 patients in the study. Twenty-five (11%) of 224 patients with molar pregnancy and 28 (7%) of 392 patients with partial molar pregnancy were diagnosed to have persistent trophoblastic tumour (PTT) requiring chemotherapy. Of the 53 patients treated for PTT, 58.5% received intravenous methotrexate (MTX), 22.6% received both MTX and actinomycin D, and 19% received CHAMOC, a multiple chemotherapeutic regimen. Four patients receiving single drug had to change the regimen because of poor response, and all recovered and remained well. There were 3 cases of recurrence, one in each group of patients receiving single, dual or multiple agents. One patient died because of treatment complication. The rest were well with a mean follow-up of 42 months. Conclusions: Post-molar serum hCG surveillance is important to detecting persistent trophoblastic activity. Early treatment of PTT by the appropriate chemotherapy has a near hundred percent cure and prevents the progression of PTT into more advanced trophoblastic malignancy such as choriocarcinoma. |
Persistent Identifier | http://hdl.handle.net/10722/173271 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 0.997 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ngan, HYS | en_US |
dc.contributor.author | Wong, LW | en_US |
dc.date.accessioned | 2012-10-30T06:28:58Z | - |
dc.date.available | 2012-10-30T06:28:58Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Chinese Medical Journal, 1999, v. 112 n. 3, p. 260-263 | en_US |
dc.identifier.issn | 0366-6999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173271 | - |
dc.description.abstract | Objective: To study the outcome of a multi-centred post-molar pregnancy serum human chorionic gonadotrophin (hCG) surveillance programme. Methods: Patients recruited into the multi-centred post-molar serum hCG surveillance programme between 1988 and 1996 were studied. The clinical data were obtained from medical records and computer database. Results: There were 616 patients in the study. Twenty-five (11%) of 224 patients with molar pregnancy and 28 (7%) of 392 patients with partial molar pregnancy were diagnosed to have persistent trophoblastic tumour (PTT) requiring chemotherapy. Of the 53 patients treated for PTT, 58.5% received intravenous methotrexate (MTX), 22.6% received both MTX and actinomycin D, and 19% received CHAMOC, a multiple chemotherapeutic regimen. Four patients receiving single drug had to change the regimen because of poor response, and all recovered and remained well. There were 3 cases of recurrence, one in each group of patients receiving single, dual or multiple agents. One patient died because of treatment complication. The rest were well with a mean follow-up of 42 months. Conclusions: Post-molar serum hCG surveillance is important to detecting persistent trophoblastic activity. Early treatment of PTT by the appropriate chemotherapy has a near hundred percent cure and prevents the progression of PTT into more advanced trophoblastic malignancy such as choriocarcinoma. | en_US |
dc.language | eng | en_US |
dc.publisher | Chinese Medical Association. The Journal's web site is located at http://www.cmj.org/ | en_US |
dc.relation.ispartof | Chinese Medical Journal | en_US |
dc.subject | Molar pregnancy | - |
dc.subject | Persistent trophoblastic tumour (PIT) | - |
dc.subject | Serum human chorionic gonadotrophin (hCG) monitoring | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Antibiotics, Antineoplastic - Therapeutic Use | en_US |
dc.subject.mesh | Antineoplastic Agents - Therapeutic Use | en_US |
dc.subject.mesh | Chorionic Gonadotropin - Blood | en_US |
dc.subject.mesh | Dactinomycin - Therapeutic Use | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydatidiform Mole - Blood | en_US |
dc.subject.mesh | Methotrexate - Therapeutic Use | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Trophoblastic Neoplasms - Blood - Diagnosis - Drug Therapy | en_US |
dc.subject.mesh | Uterine Neoplasms - Blood - Diagnosis - Drug Therapy | en_US |
dc.title | Early detection of persistent trophoblastic tumour by serum human chorionic gonadotrophin monitoring after molar pregnancy | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ngan, HYS:hysngan@hkucc.hku.hk | en_US |
dc.identifier.authority | Ngan, HYS=rp00346 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.pmid | 11593563 | - |
dc.identifier.scopus | eid_2-s2.0-0345040633 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0345040633&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 112 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 260 | en_US |
dc.identifier.epage | 263 | en_US |
dc.identifier.isi | WOS:000079139900017 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Ngan, HYS=34571944100 | en_US |
dc.identifier.scopusauthorid | Wong, LW=36947357000 | en_US |
dc.identifier.issnl | 0366-6999 | - |