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- Publisher Website: 10.1093/molehr/gah243
- Scopus: eid_2-s2.0-33645060505
- PMID: 16421213
- WOS: WOS:000235606100001
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Article: Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes
Title | Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes |
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Authors | |
Keywords | Age Deletion Mitochondrial DNA copy number Unfertilized oocyte |
Issue Date | 2006 |
Publisher | Oxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/ |
Citation | Molecular Human Reproduction, 2006, v. 11 n. 12, p. 843-846 How to Cite? |
Abstract | Previous studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp deletion was 34.6%, and the mtDNA copy number was 598 350 ± 265 862. Women ≥35 years of age had a significantly higher incidence of 4977 bp deletion, lower mtDNA copy number, higher FSH level and poorer ovarian response when compared with younger women. The mtDNA copy number was negatively correlated with the donor's age. The higher incidence of mtDNA deletion and lower mtDNA copy number in older women suggested that these two parameters may reflect ovarian ageing. © 2005 Oxford University Press. |
Persistent Identifier | http://hdl.handle.net/10722/173304 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.201 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chan, CCW | en_HK |
dc.contributor.author | Liu, VWS | en_HK |
dc.contributor.author | Lau, EYL | en_HK |
dc.contributor.author | Yeung, WSB | en_HK |
dc.contributor.author | Ng, EHY | en_HK |
dc.contributor.author | Ho, PC | en_HK |
dc.date.accessioned | 2012-10-30T06:29:11Z | - |
dc.date.available | 2012-10-30T06:29:11Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Molecular Human Reproduction, 2006, v. 11 n. 12, p. 843-846 | en_HK |
dc.identifier.issn | 1360-9947 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/173304 | - |
dc.description.abstract | Previous studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp deletion was 34.6%, and the mtDNA copy number was 598 350 ± 265 862. Women ≥35 years of age had a significantly higher incidence of 4977 bp deletion, lower mtDNA copy number, higher FSH level and poorer ovarian response when compared with younger women. The mtDNA copy number was negatively correlated with the donor's age. The higher incidence of mtDNA deletion and lower mtDNA copy number in older women suggested that these two parameters may reflect ovarian ageing. © 2005 Oxford University Press. | en_HK |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Molecular Human Reproduction | en_HK |
dc.rights | Molecular Human Reproduction. Copyright © Oxford University Press. | - |
dc.subject | Age | en_HK |
dc.subject | Deletion | en_HK |
dc.subject | Mitochondrial DNA copy number | en_HK |
dc.subject | Unfertilized oocyte | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Dna, Mitochondrial - Genetics - Isolation & Purification | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fertilization | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infertility, Female - Genetics | en_US |
dc.subject.mesh | Menstrual Cycle | en_US |
dc.subject.mesh | Oocytes - Physiology | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Sequence Deletion | en_US |
dc.title | Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Liu, VWS: vwsliu@hkusua.hku.hk | en_HK |
dc.identifier.email | Yeung, WSB: wsbyeung@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, EHY: nghye@hku.hk | en_HK |
dc.identifier.email | Ho, PC: pcho@hku.hk | en_HK |
dc.identifier.authority | Liu, VWS=rp00341 | en_HK |
dc.identifier.authority | Yeung, WSB=rp00331 | en_HK |
dc.identifier.authority | Ng, EHY=rp00426 | en_HK |
dc.identifier.authority | Ho, PC=rp00325 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/molehr/gah243 | en_HK |
dc.identifier.pmid | 16421213 | en_HK |
dc.identifier.scopus | eid_2-s2.0-33645060505 | en_HK |
dc.identifier.hkuros | 113327 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33645060505&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 843 | en_HK |
dc.identifier.epage | 846 | en_HK |
dc.identifier.isi | WOS:000235606100001 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Chan, CCW=26643394500 | en_HK |
dc.identifier.scopusauthorid | Liu, VWS=7006405113 | en_HK |
dc.identifier.scopusauthorid | Lau, EYL=7103086093 | en_HK |
dc.identifier.scopusauthorid | Yeung, WSB=7102370745 | en_HK |
dc.identifier.scopusauthorid | Ng, EHY=35238184300 | en_HK |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_HK |
dc.identifier.citeulike | 521428 | - |
dc.identifier.issnl | 1360-9947 | - |