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- Publisher Website: 10.1007/s11135-005-2071-8
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- PMID: 16946227
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Article: Human chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnancies
Title | Human chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnancies |
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Authors | |
Issue Date | 2006 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org |
Citation | Obstetrics And Gynecology, 2006, v. 108 n. 3 I, p. 651-655 How to Cite? |
Abstract | OBJECTIVE: Maternal serum free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) have been used effectively in the screening of Down syndrome in the first trimester. In this study, we aim to measure the value of first-trimester maternal serum free β-hCG and PAPP-A as predictors of homozygous α-thalassemia-affected pregnancies. METHODS: Free β-hCG and PAPP-A concentrations were measured in stored maternal serum samples obtained at 12 weeks of gestation from 22 women with fetuses affected by homozygous α-thalassemia and from 436 controls matched for maternal age, ethnicity, and weight, as well as gestation at blood sampling. RESULTS: Maternal serum concentration of free β-hCG was significantly increased in women with pregnancies affected by homozygous α-thalassemia than in controls (P=.001). Concentrations of PAPP-A did not differ between the cases affected by homozygous α-thalassemia and the controls (P=.652). CONCLUSION: Pregnancies affected by homozygous α-thalassemia are associated with increased maternal serum free β-hCG at 11-14 weeks of gestation. This serum analyte alone may not be clinically useful as a predictor of pregnancies affected by homozygous α-thalassemia. However, the absence of ultrasound features of fetal anemia and hydropic changes, together with normal maternal serum free β-hCG and PAPP-A in the first trimester, will be reassuring signs of normality for fetuses at risk of homozygous α-thalassemia and, hence, enable women to avoid invasive tests in unaffected pregnancies. © 2006 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins. |
Persistent Identifier | http://hdl.handle.net/10722/173310 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.032 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ong, CYT | en_HK |
dc.contributor.author | Lee, CP | en_HK |
dc.contributor.author | Leung, KY | en_HK |
dc.contributor.author | Lau, E | en_HK |
dc.contributor.author | Tang, MHY | en_HK |
dc.date.accessioned | 2012-10-30T06:29:13Z | - |
dc.date.available | 2012-10-30T06:29:13Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Obstetrics And Gynecology, 2006, v. 108 n. 3 I, p. 651-655 | en_HK |
dc.identifier.issn | 0029-7844 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/173310 | - |
dc.description.abstract | OBJECTIVE: Maternal serum free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) have been used effectively in the screening of Down syndrome in the first trimester. In this study, we aim to measure the value of first-trimester maternal serum free β-hCG and PAPP-A as predictors of homozygous α-thalassemia-affected pregnancies. METHODS: Free β-hCG and PAPP-A concentrations were measured in stored maternal serum samples obtained at 12 weeks of gestation from 22 women with fetuses affected by homozygous α-thalassemia and from 436 controls matched for maternal age, ethnicity, and weight, as well as gestation at blood sampling. RESULTS: Maternal serum concentration of free β-hCG was significantly increased in women with pregnancies affected by homozygous α-thalassemia than in controls (P=.001). Concentrations of PAPP-A did not differ between the cases affected by homozygous α-thalassemia and the controls (P=.652). CONCLUSION: Pregnancies affected by homozygous α-thalassemia are associated with increased maternal serum free β-hCG at 11-14 weeks of gestation. This serum analyte alone may not be clinically useful as a predictor of pregnancies affected by homozygous α-thalassemia. However, the absence of ultrasound features of fetal anemia and hydropic changes, together with normal maternal serum free β-hCG and PAPP-A in the first trimester, will be reassuring signs of normality for fetuses at risk of homozygous α-thalassemia and, hence, enable women to avoid invasive tests in unaffected pregnancies. © 2006 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins. | en_HK |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org | en_HK |
dc.relation.ispartof | Obstetrics and Gynecology | en_HK |
dc.rights | Obstetrics and Gynecology. Copyright © Lippincott Williams & Wilkins. | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Biological Markers - Analysis - Blood | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Chorionic Gonadotropin, Beta Subunit, Human - Analysis - Blood | en_US |
dc.subject.mesh | False Positive Reactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Blood - Diagnosis - Genetics | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Complications, Hematologic - Blood - Diagnosis | en_US |
dc.subject.mesh | Pregnancy Trimester, First - Blood | en_US |
dc.subject.mesh | Pregnancy-Associated Plasma Protein-A - Analysis | en_US |
dc.subject.mesh | Prenatal Diagnosis - Methods | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Alpha-Thalassemia - Blood - Diagnosis - Genetics | en_US |
dc.title | Human chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnancies | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ong, CYT: cytong@hkucc.hku.hk | en_HK |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ong, CYT=rp00482 | en_HK |
dc.identifier.authority | Tang, MHY=rp01701 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s11135-005-2071-8 | en_HK |
dc.identifier.pmid | 16946227 | - |
dc.identifier.scopus | eid_2-s2.0-33748336262 | en_HK |
dc.identifier.hkuros | 124218 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748336262&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 108 | en_HK |
dc.identifier.issue | 3 I | en_HK |
dc.identifier.spage | 651 | en_HK |
dc.identifier.epage | 655 | en_HK |
dc.identifier.isi | WOS:000239666400010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ong, CYT=7401968192 | en_HK |
dc.identifier.scopusauthorid | Lee, CP=7410149538 | en_HK |
dc.identifier.scopusauthorid | Leung, KY=8247106900 | en_HK |
dc.identifier.scopusauthorid | Lau, E=7103086081 | en_HK |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_HK |
dc.identifier.citeulike | 862193 | - |
dc.identifier.issnl | 0029-7844 | - |