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- Scopus: eid_2-s2.0-0027442854
- PMID: 7507437
- WOS: WOS:A1993MK92600004
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Conference Paper: Role of the L-arginine-nitric oxide pathway in vascular smooth muscle
Title | Role of the L-arginine-nitric oxide pathway in vascular smooth muscle |
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Authors | |
Keywords | Cyclic GMP Growth factor Nitric oxide Platelet Vascular growth Vascular injury Vascular smooth muscle Vascular tone |
Issue Date | 1993 |
Publisher | Oxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/ |
Citation | European Heart Journal, 1993, v. 14 SUPPL. I, p. 16-21 How to Cite? |
Abstract | This brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 β and tumour necrosis factor α, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide. The cytokines cause the synthesis of nitric oxide synthase(s), which catalyzes the conversion of L-arginine to nitric oxide and L-citrulline. The production of nitric oxide can be modulated by factors produced by vascular cells and formed elements of the blood (e.g. platelet-derived growth factor, transforming growth factor β), but also those generated at sites of vascular injury from inactive precursors circulating in the blood (e.g. thrombin, plasmin). The production of nitric oxide by vascular smooth muscle cells may contribute to the homeostasis of blood vessels at sites of injury. In particular, nitric oxide may prevent the local development of vasospasms, unwanted proliferation of smooth muscle cells, and also help to control coagulation and the formation of the thrombus. |
Persistent Identifier | http://hdl.handle.net/10722/173513 |
ISSN | 2023 Impact Factor: 37.6 2023 SCImago Journal Rankings: 4.091 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schini, VB | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:27Z | - |
dc.date.available | 2012-10-30T06:32:27Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | European Heart Journal, 1993, v. 14 SUPPL. I, p. 16-21 | en_US |
dc.identifier.issn | 0195-668X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173513 | - |
dc.description.abstract | This brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 β and tumour necrosis factor α, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide. The cytokines cause the synthesis of nitric oxide synthase(s), which catalyzes the conversion of L-arginine to nitric oxide and L-citrulline. The production of nitric oxide can be modulated by factors produced by vascular cells and formed elements of the blood (e.g. platelet-derived growth factor, transforming growth factor β), but also those generated at sites of vascular injury from inactive precursors circulating in the blood (e.g. thrombin, plasmin). The production of nitric oxide by vascular smooth muscle cells may contribute to the homeostasis of blood vessels at sites of injury. In particular, nitric oxide may prevent the local development of vasospasms, unwanted proliferation of smooth muscle cells, and also help to control coagulation and the formation of the thrombus. | en_US |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/ | en_US |
dc.relation.ispartof | European Heart Journal | en_US |
dc.subject | Cyclic GMP | - |
dc.subject | Growth factor | - |
dc.subject | Nitric oxide | - |
dc.subject | Platelet | - |
dc.subject | Vascular growth | - |
dc.subject | Vascular injury | - |
dc.subject | Vascular smooth muscle | - |
dc.subject | Vascular tone | - |
dc.subject.mesh | Amino Acid Oxidoreductases - Metabolism | en_US |
dc.subject.mesh | Arginine - Metabolism | en_US |
dc.subject.mesh | Blood Vessels - Injuries - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Nitric Oxide - Biosynthesis | en_US |
dc.subject.mesh | Nitric Oxide Synthase | en_US |
dc.subject.mesh | Platelet Activation - Physiology | en_US |
dc.title | Role of the L-arginine-nitric oxide pathway in vascular smooth muscle | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 7507437 | - |
dc.identifier.scopus | eid_2-s2.0-0027442854 | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | SUPPL. I | en_US |
dc.identifier.spage | 16 | en_US |
dc.identifier.epage | 21 | en_US |
dc.identifier.isi | WOS:A1993MK92600004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Schini, VB=7004113565 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0195-668X | - |