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- Publisher Website: 10.1097/00005344-199322008-00092
- Scopus: eid_2-s2.0-0027773025
- PMID: 7509985
- WOS: WOS:A1993MN02800092
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Conference Paper: Age-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery
Title | Age-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery |
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Authors | |
Keywords | Acetylcholine EDHF ET(B) receptor Spontaneously hypertensive rats Wistar-Kyoto rats |
Issue Date | 1993 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S352-S354 How to Cite? |
Abstract | The present study was designed to investigate the effects of age on the endothelium-dependent hyperpolarizing effect of endothelin-3 (ET-3) in the mesenteric artery of the rat. Main superior mesenteric arteries, with endothelium of young (7-9 weeks), adult (20-24 weeks), and old (40-50 weeks) male Wistar-Kyoto rats were studied. The cell membrane potential of the vascular smooth-muscle cells was measured with glass microelectrodes in the presence of indomethacin (inhibitor of cyclooxygenase) and N(G)-nitro-L- arginine (NLA, inhibitor of nitric oxide synthase). In preparations with endothelium from young rats, ET-3 produced transient hyperpolarizations in a concentration-dependent (10-8 to 10-9 M) manner. In tissues from adult rats, only a small hyperpolarization to the peptide was observed at 10-7 M, whereas no detectable membrane potential changes were observed in tissues from old animals. In tissues of all groups, acetylcholine produced concentration-dependent hyperpolarizations; the maximal amplitude of hyperpolarization was reduced in the old rats but no significant differences were observed in the threshold concentration for hyperpolarization to acetylcholine. These data suggest that aging decreases endothelium-dependent hyperpolarizations evoked by both ET-3 and acetylcholine. |
Persistent Identifier | http://hdl.handle.net/10722/173520 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Nakashima, M | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:29Z | - |
dc.date.available | 2012-10-30T06:32:29Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S352-S354 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173520 | - |
dc.description.abstract | The present study was designed to investigate the effects of age on the endothelium-dependent hyperpolarizing effect of endothelin-3 (ET-3) in the mesenteric artery of the rat. Main superior mesenteric arteries, with endothelium of young (7-9 weeks), adult (20-24 weeks), and old (40-50 weeks) male Wistar-Kyoto rats were studied. The cell membrane potential of the vascular smooth-muscle cells was measured with glass microelectrodes in the presence of indomethacin (inhibitor of cyclooxygenase) and N(G)-nitro-L- arginine (NLA, inhibitor of nitric oxide synthase). In preparations with endothelium from young rats, ET-3 produced transient hyperpolarizations in a concentration-dependent (10-8 to 10-9 M) manner. In tissues from adult rats, only a small hyperpolarization to the peptide was observed at 10-7 M, whereas no detectable membrane potential changes were observed in tissues from old animals. In tissues of all groups, acetylcholine produced concentration-dependent hyperpolarizations; the maximal amplitude of hyperpolarization was reduced in the old rats but no significant differences were observed in the threshold concentration for hyperpolarization to acetylcholine. These data suggest that aging decreases endothelium-dependent hyperpolarizations evoked by both ET-3 and acetylcholine. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | Acetylcholine | - |
dc.subject | EDHF | - |
dc.subject | ET(B) receptor | - |
dc.subject | Spontaneously hypertensive rats | - |
dc.subject | Wistar-Kyoto rats | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Aging - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arginine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Endothelins - Pharmacology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Membrane Potentials - Drug Effects | en_US |
dc.subject.mesh | Mesenteric Arteries - Drug Effects - Physiology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nitroarginine | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.title | Age-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-199322008-00092 | - |
dc.identifier.pmid | 7509985 | - |
dc.identifier.scopus | eid_2-s2.0-0027773025 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | SUPPL. 8 | en_US |
dc.identifier.spage | S352 | en_US |
dc.identifier.epage | S354 | en_US |
dc.identifier.isi | WOS:A1993MN02800092 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Nakashima, M=35599797500 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0160-2446 | - |