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Article: Determination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatography

TitleDetermination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatography
Authors
Li, NYu, YShen, S
KeywordsGradient Elution
Related Substance
Reversed-Phase High Performance Liquid Chromatography
Ziprasidone Hydrochloride
Issue Date2004
PublisherZhongguo Kexueyuan, Changchun Yingyong Huaxue Yanjiusuo. The Journal's web site is located at http://www.analchem.cn/
Citation
Fenxi Huaxue, 2004, v. 32 n. 7, p. 916-918 How to Cite?
AbstractA reversed-phase high performance liquid chromatographic method for analyzing ziprasidone hydrochloride and its related substances was established. The base-line separation of ziprasidone hydrochloride and 8 related substances was accomplished on a Diamonsil™ C18 (150 mm x 4.6 mm, 5 μm) column. Methanol was used as the mobile phase A, while acetate buffer at pH 6.0 was employed as mobile phase B. Gradient elution was adopted at the detection of 254 nm with a diode array detector. The limit of detection of each related substance can satisfy for quality control purpose. It is simple, reproducible and accurate.
Persistent Identifierhttp://hdl.handle.net/10722/175139
ISSN
0253-3820
2021 Impact Factor: 1.193
2019 SCImago Journal Rankings: 0.569
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Nen_US
dc.contributor.authorYu, Yen_US
dc.contributor.authorShen, Sen_US
dc.date.accessioned2012-11-26T08:49:23Z-
dc.date.available2012-11-26T08:49:23Z-
dc.date.issued2004en_US
dc.identifier.citationFenxi Huaxue, 2004, v. 32 n. 7, p. 916-918en_US
dc.identifier.issn0253-3820en_US
dc.identifier.urihttp://hdl.handle.net/10722/175139-
dc.description.abstractA reversed-phase high performance liquid chromatographic method for analyzing ziprasidone hydrochloride and its related substances was established. The base-line separation of ziprasidone hydrochloride and 8 related substances was accomplished on a Diamonsil™ C18 (150 mm x 4.6 mm, 5 μm) column. Methanol was used as the mobile phase A, while acetate buffer at pH 6.0 was employed as mobile phase B. Gradient elution was adopted at the detection of 254 nm with a diode array detector. The limit of detection of each related substance can satisfy for quality control purpose. It is simple, reproducible and accurate.en_US
dc.languageengen_US
dc.publisherZhongguo Kexueyuan, Changchun Yingyong Huaxue Yanjiusuo. The Journal's web site is located at http://www.analchem.cn/en_US
dc.relation.ispartofFenxi Huaxueen_US
dc.subjectGradient Elutionen_US
dc.subjectRelated Substanceen_US
dc.subjectReversed-Phase High Performance Liquid Chromatographyen_US
dc.subjectZiprasidone Hydrochlorideen_US
dc.titleDetermination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatographyen_US
dc.typeArticleen_US
dc.identifier.emailShen, S: sshen@hkucc.hku.hken_US
dc.identifier.authorityShen, S=rp00775en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-4444332641en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444332641&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue7en_US
dc.identifier.spage916en_US
dc.identifier.epage918en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLi, N=27170796800en_US
dc.identifier.scopusauthoridYu, Y=8572872900en_US
dc.identifier.scopusauthoridShen, S=7403431266en_US
dc.identifier.issnl0253-3820-

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