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- Publisher Website: 10.1111/j.1440-1681.1978.tb00687.x
- Scopus: eid_2-s2.0-0018069375
- PMID: 699381
- WOS: WOS:A1978FP29200010
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Article: Effect of cimetidine on the healing of restraint-induced gastric erosions in the rat
Title | Effect of cimetidine on the healing of restraint-induced gastric erosions in the rat |
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Authors | |
Keywords | acid secretion gastric erosion histamine antagonist rat |
Issue Date | 1978 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 4, p. 383-385 How to Cite? |
Abstract | Rats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint. |
Persistent Identifier | http://hdl.handle.net/10722/175603 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Clarke, AC | en_US |
dc.contributor.author | TasmanJones, C | en_US |
dc.date.accessioned | 2012-11-26T09:00:06Z | - |
dc.date.available | 2012-11-26T09:00:06Z | - |
dc.date.issued | 1978 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 4, p. 383-385 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175603 | - |
dc.description.abstract | Rats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | acid secretion | - |
dc.subject | gastric erosion | - |
dc.subject | histamine antagonist | - |
dc.subject | rat | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cimetidine - Therapeutic Use | en_US |
dc.subject.mesh | Guanidines - Therapeutic Use | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Placebos | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Restraint, Physical | en_US |
dc.subject.mesh | Stomach Ulcer - Drug Therapy - Etiology | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Effect of cimetidine on the healing of restraint-induced gastric erosions in the rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1978.tb00687.x | - |
dc.identifier.pmid | 699381 | - |
dc.identifier.scopus | eid_2-s2.0-0018069375 | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 383 | en_US |
dc.identifier.epage | 385 | en_US |
dc.identifier.isi | WOS:A1978FP29200010 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Clarke, AC=7403682654 | en_US |
dc.identifier.scopusauthorid | TasmanJones, C=7003303326 | en_US |
dc.identifier.issnl | 0305-1870 | - |