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- Publisher Website: 10.1111/j.1440-1681.1978.tb00652.x
- Scopus: eid_2-s2.0-0018134601
- PMID: 639359
- WOS: WOS:A1978EM29000008
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Article: Prevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist
Title | Prevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist |
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Authors | |
Keywords | acute gastric ulcers histamine H2‐receptor antagonist rats |
Issue Date | 1978 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 1, p. 61-66 How to Cite? |
Abstract | Intraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 μmol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d.=0.28): the difference was highly significant (P<0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 μmol/min (s.d.=0.12;P<0.001). Treatment with cimetidine in doses of 100 mg/kg 8-hourly during a 24 h period of restraint prevented the development of acute gastric ulceration in the rat. Pretreatment with cimetidine also protected against the ulcerogenic effects of intragastrically administered bile or lysolecithin. The marked sustained reduction of acid production most probably accounts for the protective effect of cimetidine against ulcer production in the rat stomach. |
Persistent Identifier | http://hdl.handle.net/10722/175604 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | TasmanJones, C | en_US |
dc.date.accessioned | 2012-11-26T09:00:06Z | - |
dc.date.available | 2012-11-26T09:00:06Z | - |
dc.date.issued | 1978 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 1, p. 61-66 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175604 | - |
dc.description.abstract | Intraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 μmol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d.=0.28): the difference was highly significant (P<0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 μmol/min (s.d.=0.12;P<0.001). Treatment with cimetidine in doses of 100 mg/kg 8-hourly during a 24 h period of restraint prevented the development of acute gastric ulceration in the rat. Pretreatment with cimetidine also protected against the ulcerogenic effects of intragastrically administered bile or lysolecithin. The marked sustained reduction of acid production most probably accounts for the protective effect of cimetidine against ulcer production in the rat stomach. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | acute gastric ulcers | - |
dc.subject | histamine H2‐receptor antagonist | - |
dc.subject | rats | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bile - Physiology | en_US |
dc.subject.mesh | Cimetidine - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Gastric Juice - Secretion | en_US |
dc.subject.mesh | Guanidines - Therapeutic Use | en_US |
dc.subject.mesh | Lysophosphatidylcholines - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Restraint, Physical | en_US |
dc.subject.mesh | Stomach Ulcer - Chemically Induced - Prevention & Control | en_US |
dc.title | Prevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1978.tb00652.x | - |
dc.identifier.pmid | 639359 | - |
dc.identifier.scopus | eid_2-s2.0-0018134601 | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 61 | en_US |
dc.identifier.epage | 66 | en_US |
dc.identifier.isi | WOS:A1978EM29000008 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | TasmanJones, C=7003303326 | en_US |
dc.identifier.issnl | 0305-1870 | - |