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- Scopus: eid_2-s2.0-0022490239
- PMID: 3728645
- WOS: WOS:A1986D198200003
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Article: Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology
Title | Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology |
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Authors | |
Issue Date | 1986 |
Publisher | American Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org |
Citation | American Journal Of Pathology, 1986, v. 124 n. 1, p. 18-24 How to Cite? |
Abstract | Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation. |
Persistent Identifier | http://hdl.handle.net/10722/175640 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.647 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | TasmanJones, C | en_US |
dc.contributor.author | Carlisle, V | en_US |
dc.date.accessioned | 2012-11-26T09:00:14Z | - |
dc.date.available | 2012-11-26T09:00:14Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | American Journal Of Pathology, 1986, v. 124 n. 1, p. 18-24 | en_US |
dc.identifier.issn | 0002-9440 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175640 | - |
dc.description.abstract | Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org | en_US |
dc.relation.ispartof | American Journal of Pathology | en_US |
dc.subject.mesh | Administration, Oral | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bile Acids And Salts - Analysis - Biosynthesis | en_US |
dc.subject.mesh | Cholelithiasis - Chemically Induced - Pathology | en_US |
dc.subject.mesh | Cholesterol - Analysis | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gallbladder - Drug Effects - Metabolism - Pathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Oleic Acid | en_US |
dc.subject.mesh | Oleic Acids - Pharmacology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.title | Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3728645 | - |
dc.identifier.scopus | eid_2-s2.0-0022490239 | en_US |
dc.identifier.volume | 124 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 18 | en_US |
dc.identifier.epage | 24 | en_US |
dc.identifier.isi | WOS:A1986D198200003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | TasmanJones, C=7003303326 | en_US |
dc.identifier.scopusauthorid | Carlisle, V=6602101145 | en_US |
dc.identifier.issnl | 0002-9440 | - |