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- Publisher Website: 10.1111/j.1600-0447.1993.tb03468.x
- Scopus: eid_2-s2.0-0027491430
- PMID: 8296576
- WOS: WOS:A1993MG11100005
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Article: Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia?
Title | Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia? |
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Authors | |
Keywords | affective disorder genotype influenza phenotype schizophrenia |
Issue Date | 1993 |
Publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP |
Citation | Acta Psychiatrica Scandinavica, 1993, v. 88 n. 5, p. 328-336 How to Cite? |
Abstract | We examined the relationship between influenza epidemics and the number of schizophrenic and affective psychotic individuals born each month between 1938 and 1965 in England and Wales. Increased death rates from influenza were followed 5 months later by a significant increase in schizophrenic births and a concurrent fall in the number of births of affective psychotic individuals. When the sexes were examined separately, both the positive effect of influenza on schizophrenic births and its negative effect on affective psychotic births were evident for females but not for males. Furthermore, during February to June in high influenza years, there was an inverse relationship between the number of female schizophrenic and affective psychotic births. The explanation for these surprising findings may be that prenatal exposure to influenza impairs the neurodevelopment of some females with a predisposition to affective psychosis, in such a way that their later illness shows schizophrenic rather than affective features. |
Persistent Identifier | http://hdl.handle.net/10722/175685 |
ISSN | 2021 Impact Factor: 7.734 2020 SCImago Journal Rankings: 2.849 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Takei, N | en_US |
dc.contributor.author | O'callaghan, E | en_US |
dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Glover, G | en_US |
dc.contributor.author | Murray, RM | en_US |
dc.date.accessioned | 2012-11-26T09:00:29Z | - |
dc.date.available | 2012-11-26T09:00:29Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Acta Psychiatrica Scandinavica, 1993, v. 88 n. 5, p. 328-336 | en_US |
dc.identifier.issn | 0001-690X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175685 | - |
dc.description.abstract | We examined the relationship between influenza epidemics and the number of schizophrenic and affective psychotic individuals born each month between 1938 and 1965 in England and Wales. Increased death rates from influenza were followed 5 months later by a significant increase in schizophrenic births and a concurrent fall in the number of births of affective psychotic individuals. When the sexes were examined separately, both the positive effect of influenza on schizophrenic births and its negative effect on affective psychotic births were evident for females but not for males. Furthermore, during February to June in high influenza years, there was an inverse relationship between the number of female schizophrenic and affective psychotic births. The explanation for these surprising findings may be that prenatal exposure to influenza impairs the neurodevelopment of some females with a predisposition to affective psychosis, in such a way that their later illness shows schizophrenic rather than affective features. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP | en_US |
dc.relation.ispartof | Acta Psychiatrica Scandinavica | en_US |
dc.subject | affective disorder | - |
dc.subject | genotype | - |
dc.subject | influenza | - |
dc.subject | phenotype | - |
dc.subject | schizophrenia | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Affective Disorders, Psychotic - Epidemiology - Etiology | en_US |
dc.subject.mesh | Cross-Sectional Studies | en_US |
dc.subject.mesh | Delirium, Dementia, Amnestic, Cognitive Disorders - Epidemiology - Etiology | en_US |
dc.subject.mesh | Disease Outbreaks | en_US |
dc.subject.mesh | England - Epidemiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Incidence | en_US |
dc.subject.mesh | Infant, Newborn | en_US |
dc.subject.mesh | Influenza, Human - Complications - Epidemiology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Poisson Distribution | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prenatal Exposure Delayed Effects | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Schizophrenia - Epidemiology - Etiology | en_US |
dc.subject.mesh | Schizophrenic Psychology | en_US |
dc.subject.mesh | Seasons | en_US |
dc.subject.mesh | Sex Factors | en_US |
dc.subject.mesh | Wales - Epidemiology | en_US |
dc.title | Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1600-0447.1993.tb03468.x | - |
dc.identifier.pmid | 8296576 | - |
dc.identifier.scopus | eid_2-s2.0-0027491430 | en_US |
dc.identifier.volume | 88 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 328 | en_US |
dc.identifier.epage | 336 | en_US |
dc.identifier.isi | WOS:A1993MG11100005 | - |
dc.publisher.place | Denmark | en_US |
dc.identifier.scopusauthorid | Takei, N=35874982900 | en_US |
dc.identifier.scopusauthorid | O'Callaghan, E=7005694363 | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Glover, G=7102248539 | en_US |
dc.identifier.scopusauthorid | Murray, RM=35406239400 | en_US |
dc.identifier.issnl | 0001-690X | - |