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Article: Systematic search for major genes in schizophrenia: Methodological issues and results from chromosome 12

TitleSystematic search for major genes in schizophrenia: Methodological issues and results from chromosome 12
Authors
Dawson, EPowell, JFSham, PShaikh, STaylor, CClements, AAsherson, PSargeant, MCollier, DNanko, SWhatley, SMurray, RMcguffin, POwen, MGill, M
Keywordschromosome 12
heterogeneity
linkage
schizophrenia
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 424-433 How to Cite?
DOI: http://dx.doi.org/10.1002/ajmg.1320600513
AbstractWe describe a method of systematically searching for major genes in disorders of unknown mode of inheritance, using linkage analysis. Our method is designed to minimize the probability of missing linkage due to inadequate exploration of data. We illustrate this method with the results of a search for a locus for schizophrenia on chromosome 12 using 22 highly polymorphic markers in 23 high density pedigrees. The markers span approximately 85-90% of the chromosome and are on average 9.35 cM apart. We have analysed the data using the most plausible current genetic models and allowing for the presence of genetic heterogeneity. None of the markers was supportive of linkage and the distribution of the heterogeneity statistics was in accordance with the null hypothesis.
Persistent Identifierhttp://hdl.handle.net/10722/175711
ISSN
0148-7299
ISI Accession Number ID
WOS:A1995RZ63800012

 

DC FieldValueLanguage
dc.contributor.authorDawson, Een_US
dc.contributor.authorPowell, JFen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorShaikh, Sen_US
dc.contributor.authorTaylor, Cen_US
dc.contributor.authorClements, Aen_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorSargeant, Men_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorNanko, Sen_US
dc.contributor.authorWhatley, Sen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorGill, Men_US
dc.date.accessioned2012-11-26T09:00:40Z-
dc.date.available2012-11-26T09:00:40Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 424-433en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175711-
dc.description.abstractWe describe a method of systematically searching for major genes in disorders of unknown mode of inheritance, using linkage analysis. Our method is designed to minimize the probability of missing linkage due to inadequate exploration of data. We illustrate this method with the results of a search for a locus for schizophrenia on chromosome 12 using 22 highly polymorphic markers in 23 high density pedigrees. The markers span approximately 85-90% of the chromosome and are on average 9.35 cM apart. We have analysed the data using the most plausible current genetic models and allowing for the presence of genetic heterogeneity. None of the markers was supportive of linkage and the distribution of the heterogeneity statistics was in accordance with the null hypothesis.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subjectchromosome 12-
dc.subjectheterogeneity-
dc.subjectlinkage-
dc.subjectschizophrenia-
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Heterogeneityen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPedigreeen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleSystematic search for major genes in schizophrenia: Methodological issues and results from chromosome 12en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600513en_US
dc.identifier.pmid8546156-
dc.identifier.scopuseid_2-s2.0-0028803713en_US
dc.identifier.volume60en_US
dc.identifier.issue5en_US
dc.identifier.spage424en_US
dc.identifier.epage433en_US
dc.identifier.isiWOS:A1995RZ63800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDawson, E=7102147964en_US
dc.identifier.scopusauthoridPowell, JF=7403541196en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridShaikh, S=36485513100en_US
dc.identifier.scopusauthoridTaylor, C=35515761100en_US
dc.identifier.scopusauthoridClements, A=55254952200en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridSargeant, M=6602805309en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridNanko, S=7006294283en_US
dc.identifier.scopusauthoridWhatley, S=7006408211en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.issnl0148-7299-

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