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- Publisher Website: 10.1002/ajmg.1320600506
- Scopus: eid_2-s2.0-0028864732
- PMID: 8546149
- WOS: WOS:A1995RZ63800005
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Article: Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected families
Title | Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected families |
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Authors | |
Keywords | psychosis sib-pair analysis X-chromosome |
Issue Date | 1995 |
Citation | American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 377-381 How to Cite? |
Abstract | Crow et al. [1993: Am J Med Genet (Neuropsychiatr Genet) 48:159-160] have reported excess sharing of alleles by male sibling pairs with schizophrenia, at a triplet repeat marker within the androgen receptor gene, indicating that mutations at or near this gene may be a risk factor for males. In this report, we describe a pair of male siblings concordant for both schizophrenia and Reifenstein syndrome, which is caused by a mutation in this gene. This provides support for the hypothesis that the androgen receptor may contribute to liability to develop schizophrenia. Because of this, we have examined a collection of 23 pedigrees multiply affected by schizophrenia for linkage to the androgen receptor. We have found no evidence for linkage by both the LOD score and affected sibling-pair methods, under a range of genetic models with a broad and narrow definition of phenotype, and when families with male-to- male transmission are excluded. However, because of the small number of informative male-male pairs in our sample, we cannot confirm or refute the excess allele sharing for males reported by Crow. |
Persistent Identifier | http://hdl.handle.net/10722/175715 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Arranz, M | en_US |
dc.contributor.author | Sharma, T | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Kerwin, R | en_US |
dc.contributor.author | Nanko, S | en_US |
dc.contributor.author | Owen, M | en_US |
dc.contributor.author | Gill, M | en_US |
dc.contributor.author | Collier, D | en_US |
dc.date.accessioned | 2012-11-26T09:00:42Z | - |
dc.date.available | 2012-11-26T09:00:42Z | - |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 377-381 | en_US |
dc.identifier.issn | 0148-7299 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175715 | - |
dc.description.abstract | Crow et al. [1993: Am J Med Genet (Neuropsychiatr Genet) 48:159-160] have reported excess sharing of alleles by male sibling pairs with schizophrenia, at a triplet repeat marker within the androgen receptor gene, indicating that mutations at or near this gene may be a risk factor for males. In this report, we describe a pair of male siblings concordant for both schizophrenia and Reifenstein syndrome, which is caused by a mutation in this gene. This provides support for the hypothesis that the androgen receptor may contribute to liability to develop schizophrenia. Because of this, we have examined a collection of 23 pedigrees multiply affected by schizophrenia for linkage to the androgen receptor. We have found no evidence for linkage by both the LOD score and affected sibling-pair methods, under a range of genetic models with a broad and narrow definition of phenotype, and when families with male-to- male transmission are excluded. However, because of the small number of informative male-male pairs in our sample, we cannot confirm or refute the excess allele sharing for males reported by Crow. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | American Journal of Medical Genetics - Neuropsychiatric Genetics | en_US |
dc.subject | psychosis | - |
dc.subject | sib-pair analysis | - |
dc.subject | X-chromosome | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Disorders Of Sex Development - Genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Linkage | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Mutation | en_US |
dc.subject.mesh | Pedigree | en_US |
dc.subject.mesh | Receptors, Androgen - Genetics | en_US |
dc.subject.mesh | Schizophrenia - Genetics - Metabolism | en_US |
dc.subject.mesh | Syndrome | en_US |
dc.subject.mesh | X Chromosome | en_US |
dc.title | Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected families | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/ajmg.1320600506 | en_US |
dc.identifier.pmid | 8546149 | - |
dc.identifier.scopus | eid_2-s2.0-0028864732 | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 377 | en_US |
dc.identifier.epage | 381 | en_US |
dc.identifier.isi | WOS:A1995RZ63800005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Arranz, M=7006010757 | en_US |
dc.identifier.scopusauthorid | Sharma, T=7202571892 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Kerwin, R=7102904567 | en_US |
dc.identifier.scopusauthorid | Nanko, S=7006294283 | en_US |
dc.identifier.scopusauthorid | Owen, M=36044041500 | en_US |
dc.identifier.scopusauthorid | Gill, M=14633481100 | en_US |
dc.identifier.scopusauthorid | Collier, D=26642980600 | en_US |
dc.identifier.issnl | 0148-7299 | - |