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Article: Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder

TitleEvidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder
Authors
Lim, LCCPowell, JSham, PCastle, DHunt, NMurray, RGill, M
Keywordsaffective disorder
association study
chromosome X
manic depression
MAOA gene
MAOB gene
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 4, p. 325-331 How to Cite?
DOI: http://dx.doi.org/10.1002/ajmg.1320600413
AbstractWe present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism. The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB. Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions. Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes. The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant.
Persistent Identifierhttp://hdl.handle.net/10722/175730
ISSN
0148-7299
ISI Accession Number ID
WOS:A1995RN77300012

 

DC FieldValueLanguage
dc.contributor.authorLim, LCCen_US
dc.contributor.authorPowell, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorCastle, Den_US
dc.contributor.authorHunt, Nen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorGill, Men_US
dc.date.accessioned2012-11-26T09:00:49Z-
dc.date.available2012-11-26T09:00:49Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 4, p. 325-331en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175730-
dc.description.abstractWe present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism. The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB. Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions. Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes. The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subjectaffective disorder-
dc.subjectassociation study-
dc.subjectchromosome X-
dc.subjectmanic depression-
dc.subjectMAOA gene-
dc.subjectMAOB gene-
dc.subject.meshAllelesen_US
dc.subject.meshBipolar Disorder - Genetics - Psychologyen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMinisatellite Repeatsen_US
dc.subject.meshMonoamine Oxidase - Geneticsen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.titleEvidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorderen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600413en_US
dc.identifier.pmid7485270-
dc.identifier.scopuseid_2-s2.0-0029089851en_US
dc.identifier.volume60en_US
dc.identifier.issue4en_US
dc.identifier.spage325en_US
dc.identifier.epage331en_US
dc.identifier.isiWOS:A1995RN77300012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLim, LCC=36484937000en_US
dc.identifier.scopusauthoridPowell, J=7403541196en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridCastle, D=16149153500en_US
dc.identifier.scopusauthoridHunt, N=36484660400en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US
dc.identifier.issnl0148-7299-

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