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Article: Association between clozapine response and allelic variation in 5-HT(2A) receptor gene

TitleAssociation between clozapine response and allelic variation in 5-HT(2A) receptor gene
Authors
Arranz, MCollier, DSodhi, MBall, DRoberts, GPrice, JSham, PKerwin, R
Issue Date1995
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 1995, v. 346 n. 8970, p. 281-282 How to Cite?
DOI: http://dx.doi.org/10.1016/S0140-6736(95)92168-0
AbstractWe report allelic association between a polymorphism (T102C) within the coding region of the 5-HT(2A) gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.
Persistent Identifierhttp://hdl.handle.net/10722/175732
ISSN
0140-6736
2023 Impact Factor: 98.4
2023 SCImago Journal Rankings: 12.113
ISI Accession Number ID
WOS:A1995RL75700013

 

DC FieldValueLanguage
dc.contributor.authorArranz, Men_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorBall, Den_US
dc.contributor.authorRoberts, Gen_US
dc.contributor.authorPrice, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKerwin, Ren_US
dc.date.accessioned2012-11-26T09:00:49Z-
dc.date.available2012-11-26T09:00:49Z-
dc.date.issued1995en_US
dc.identifier.citationLancet, 1995, v. 346 n. 8970, p. 281-282en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/175732-
dc.description.abstractWe report allelic association between a polymorphism (T102C) within the coding region of the 5-HT(2A) gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAllelesen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshClozapine - Pharmacology - Therapeutic Useen_US
dc.subject.meshDna Primersen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variation - Drug Effectsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Genetic - Drug Effectsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2aen_US
dc.subject.meshReceptors, Serotonin - Drug Effects - Geneticsen_US
dc.subject.meshSchizophrenia - Drug Therapy - Geneticsen_US
dc.titleAssociation between clozapine response and allelic variation in 5-HT(2A) receptor geneen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(95)92168-0-
dc.identifier.pmid7630250-
dc.identifier.scopuseid_2-s2.0-0029100429en_US
dc.identifier.volume346en_US
dc.identifier.issue8970en_US
dc.identifier.spage281en_US
dc.identifier.epage282en_US
dc.identifier.isiWOS:A1995RL75700013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridArranz, M=7006010757en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridRoberts, G=7403400681en_US
dc.identifier.scopusauthoridPrice, J=7404020184en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKerwin, R=7102904567en_US
dc.identifier.issnl0140-6736-

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