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Article: Association between clozapine response and allelic variation in the 5-HT(2C) receptor gene

TitleAssociation between clozapine response and allelic variation in the 5-HT(2C) receptor gene
Authors
Sodhi, MSArranz, MJCurtis, DBall, DMSham, PRoberts, GWPrice, JCollier, DAKerwin, RW
Keywords5-HT2c receptor
Amino acid substitution
Association study
Clozapine
Genotype
Schizophrenia
Issue Date1995
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 1995, v. 7 n. 1, p. 169-172 How to Cite?
DOI: http://dx.doi.org/10.1097/00001756-199512000-00041
AbstractA cysteine to serine substitution at amino acid 23 in the 5-HT(2C) receptor gene alters the pharmacological properties of the protein. We investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between the disease state or clinical response to the atypical antipsychotic drug, clozapine. Ninety percent of subjects who had one or more 5-HT(2C)ser alleles (19/21) were classified as clozapine responders compared with 59% (84/141) without this allele (χ2 = 7.7, p = 0.005), suggesting that this mutation is a predictor of good response to clozapine. There was no association between schizophrenia and the 5-HT(2C)ser allele, but our results indicate that the 5-HT(2C) receptor may contain the major site of action through which clozapine mediates its antipsychotic effects.
Persistent Identifierhttp://hdl.handle.net/10722/175736
ISSN
0959-4965
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.459
ISI Accession Number ID
WOS:A1995TX36900041

 

DC FieldValueLanguage
dc.contributor.authorSodhi, MSen_US
dc.contributor.authorArranz, MJen_US
dc.contributor.authorCurtis, Den_US
dc.contributor.authorBall, DMen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorRoberts, GWen_US
dc.contributor.authorPrice, Jen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:00:51Z-
dc.date.available2012-11-26T09:00:51Z-
dc.date.issued1995en_US
dc.identifier.citationNeuroreport, 1995, v. 7 n. 1, p. 169-172en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/175736-
dc.description.abstractA cysteine to serine substitution at amino acid 23 in the 5-HT(2C) receptor gene alters the pharmacological properties of the protein. We investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between the disease state or clinical response to the atypical antipsychotic drug, clozapine. Ninety percent of subjects who had one or more 5-HT(2C)ser alleles (19/21) were classified as clozapine responders compared with 59% (84/141) without this allele (χ2 = 7.7, p = 0.005), suggesting that this mutation is a predictor of good response to clozapine. There was no association between schizophrenia and the 5-HT(2C)ser allele, but our results indicate that the 5-HT(2C) receptor may contain the major site of action through which clozapine mediates its antipsychotic effects.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject5-HT2c receptor-
dc.subjectAmino acid substitution-
dc.subjectAssociation study-
dc.subjectClozapine-
dc.subjectGenotype-
dc.subjectSchizophrenia-
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Therapeutic Useen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshClozapine - Therapeutic Useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSchizophrenia - Drug Therapy - Geneticsen_US
dc.subject.meshSerotonin Antagonists - Therapeutic Useen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAssociation between clozapine response and allelic variation in the 5-HT(2C) receptor geneen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00001756-199512000-00041-
dc.identifier.pmid8742444-
dc.identifier.scopuseid_2-s2.0-0029551796en_US
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.spage169en_US
dc.identifier.epage172en_US
dc.identifier.isiWOS:A1995TX36900041-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSodhi, MS=7004463507en_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridCurtis, D=14633020700en_US
dc.identifier.scopusauthoridBall, DM=7202703810en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridRoberts, GW=7403400681en_US
dc.identifier.scopusauthoridPrice, J=7404020184en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US
dc.identifier.issnl0959-4965-

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