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- Scopus: eid_2-s2.0-0029913969
- PMID: 8968638
- WOS: WOS:A1996VX57000017
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Article: Morbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosis
Title | Morbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosis |
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Authors | |
Issue Date | 1996 |
Publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ |
Citation | British Journal Of Psychiatry, 1996, v. 169 n. 6, p. 776-780 How to Cite? |
Abstract | Background. The high rate of schizophrenia among the second-generation African-Caribbean population in Britain has prompted much concern and speculation. Sugarman and Craufurd have reported that the morbid risk in the siblings of second-generation African-Caribbean schizophrenic patients was unusually high compared with that of the siblings of White patients. Method. We sought to replicate these findings by comparing the morbid risk for schizophrenia in the first-degree relatives of 111 White and 73 African-Caribbean psychotic probands. The latter comprised 35 first-generation (born in the Caribbean) and 38 second-generation (born in Britain) probands. Results. The morbid risk for schizophrenia was similar for the parents and siblings of White and first-generation African-Caribbean patients, and for the parents of the second-generation African-Caribbean probands. However, the siblings of second-generation African-Caribbean psychotic probands had a morbid risk for schizophrenia that was seven times that of their White counterparts (P=0.007); similarly, the siblings of second-generation African-Caribbean schizophrenic probands had a morbid risk for schizophrenia that was four times that of their White counterparts (P=0.05). Conclusions. These findings replicate those of the earlier report of Sugarman and Craufurd, and suggest either that the second-generation African-Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Britain. |
Persistent Identifier | http://hdl.handle.net/10722/175748 |
ISSN | 2022 Impact Factor: 10.5 2020 SCImago Journal Rankings: 2.564 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hutchinson, G | en_US |
dc.contributor.author | Takei, N | en_US |
dc.contributor.author | Fahy, TA | en_US |
dc.contributor.author | Bhugra, D | en_US |
dc.contributor.author | Gilvarry, C | en_US |
dc.contributor.author | Moran, P | en_US |
dc.contributor.author | Mallett, R | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Leff, J | en_US |
dc.contributor.author | Murray, RM | en_US |
dc.date.accessioned | 2012-11-26T09:00:57Z | - |
dc.date.available | 2012-11-26T09:00:57Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | British Journal Of Psychiatry, 1996, v. 169 n. 6, p. 776-780 | en_US |
dc.identifier.issn | 0007-1250 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175748 | - |
dc.description.abstract | Background. The high rate of schizophrenia among the second-generation African-Caribbean population in Britain has prompted much concern and speculation. Sugarman and Craufurd have reported that the morbid risk in the siblings of second-generation African-Caribbean schizophrenic patients was unusually high compared with that of the siblings of White patients. Method. We sought to replicate these findings by comparing the morbid risk for schizophrenia in the first-degree relatives of 111 White and 73 African-Caribbean psychotic probands. The latter comprised 35 first-generation (born in the Caribbean) and 38 second-generation (born in Britain) probands. Results. The morbid risk for schizophrenia was similar for the parents and siblings of White and first-generation African-Caribbean patients, and for the parents of the second-generation African-Caribbean probands. However, the siblings of second-generation African-Caribbean psychotic probands had a morbid risk for schizophrenia that was seven times that of their White counterparts (P=0.007); similarly, the siblings of second-generation African-Caribbean schizophrenic probands had a morbid risk for schizophrenia that was four times that of their White counterparts (P=0.05). Conclusions. These findings replicate those of the earlier report of Sugarman and Craufurd, and suggest either that the second-generation African-Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Britain. | en_US |
dc.language | eng | en_US |
dc.publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ | en_US |
dc.relation.ispartof | British Journal of Psychiatry | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Africa - Ethnology | en_US |
dc.subject.mesh | African Americans - Psychology | en_US |
dc.subject.mesh | African Continental Ancestry Group - Genetics | en_US |
dc.subject.mesh | Child Of Impaired Parents - Psychology | en_US |
dc.subject.mesh | Cross-Cultural Comparison | en_US |
dc.subject.mesh | European Continental Ancestry Group - Genetics - Psychology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Great Britain - Epidemiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Phenotype | en_US |
dc.subject.mesh | Psychotic Disorders - Diagnosis - Ethnology - Genetics | en_US |
dc.subject.mesh | Risk | en_US |
dc.subject.mesh | Schizophrenia - Diagnosis - Ethnology - Genetics | en_US |
dc.subject.mesh | Social Environment | en_US |
dc.subject.mesh | West Indies - Ethnology | en_US |
dc.title | Morbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1192/bjp.169.6.776 | - |
dc.identifier.pmid | 8968638 | - |
dc.identifier.scopus | eid_2-s2.0-0029913969 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029913969&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 169 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 776 | en_US |
dc.identifier.epage | 780 | en_US |
dc.identifier.isi | WOS:A1996VX57000017 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Hutchinson, G=35113301500 | en_US |
dc.identifier.scopusauthorid | Takei, N=7102701392 | en_US |
dc.identifier.scopusauthorid | Fahy, TA=8077630100 | en_US |
dc.identifier.scopusauthorid | Bhugra, D=7006858005 | en_US |
dc.identifier.scopusauthorid | Gilvarry, C=6701857173 | en_US |
dc.identifier.scopusauthorid | Moran, P=34571973600 | en_US |
dc.identifier.scopusauthorid | Mallett, R=7004817370 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Leff, J=7102081288 | en_US |
dc.identifier.scopusauthorid | Murray, RM=35406239400 | en_US |
dc.identifier.issnl | 0007-1250 | - |