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- Publisher Website: 10.1016/S0889-8553(05)70045-5
- Scopus: eid_2-s2.0-0032908387
- PMID: 10198780
- WOS: WOS:000079639700006
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Article: Gallstone formation: Local factors
Title | Gallstone formation: Local factors |
---|---|
Authors | |
Issue Date | 1999 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.gastro.theclinics.com/ |
Citation | Gastroenterology Clinics Of North America, 1999, v. 28 n. 1, p. 99-115 How to Cite? |
Abstract | Supersaturation of bile is a necessary prerequisite to gallstone formation. However, patients who have undergone a cholecystectomy do not form gallstones. This indicates a role of local factors in gallstone formation. Gallbladder stasis, mucin secretion, the presence of pronucleating and antinucleating biliary proteins, and some medications have been shown to alter gallstone formation. New data has also caused the role of bacterial infection in gallstone pathogenesis to be re-examined. In addition, genetic factors have recently been identified which may predispose to gallstone formation by altering the secretion of hepatic bile. |
Persistent Identifier | http://hdl.handle.net/10722/175802 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 1.026 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, CW | en_US |
dc.contributor.author | Lee, SP | en_US |
dc.date.accessioned | 2012-11-26T09:01:25Z | - |
dc.date.available | 2012-11-26T09:01:25Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Gastroenterology Clinics Of North America, 1999, v. 28 n. 1, p. 99-115 | en_US |
dc.identifier.issn | 0889-8553 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175802 | - |
dc.description.abstract | Supersaturation of bile is a necessary prerequisite to gallstone formation. However, patients who have undergone a cholecystectomy do not form gallstones. This indicates a role of local factors in gallstone formation. Gallbladder stasis, mucin secretion, the presence of pronucleating and antinucleating biliary proteins, and some medications have been shown to alter gallstone formation. New data has also caused the role of bacterial infection in gallstone pathogenesis to be re-examined. In addition, genetic factors have recently been identified which may predispose to gallstone formation by altering the secretion of hepatic bile. | en_US |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.gastro.theclinics.com/ | en_US |
dc.relation.ispartof | Gastroenterology Clinics of North America | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apolipoproteins E - Genetics | en_US |
dc.subject.mesh | Ceftriaxone - Adverse Effects | en_US |
dc.subject.mesh | Cephalosporins - Adverse Effects | en_US |
dc.subject.mesh | Cholelithiasis - Etiology - Metabolism | en_US |
dc.subject.mesh | Gastrointestinal Agents - Adverse Effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infection - Complications | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Octreotide - Adverse Effects | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.title | Gallstone formation: Local factors | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0889-8553(05)70045-5 | en_US |
dc.identifier.pmid | 10198780 | - |
dc.identifier.scopus | eid_2-s2.0-0032908387 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 99 | en_US |
dc.identifier.epage | 115 | en_US |
dc.identifier.isi | WOS:000079639700006 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Ko, CW=7202596492 | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.issnl | 0889-8553 | - |