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- Publisher Website: 10.1128/JVI.74.16.7642-7645.2000
- Scopus: eid_2-s2.0-0033865631
- PMID: 10906219
- WOS: WOS:000088342400047
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Article: Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors
Title | Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors |
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Authors | |
Issue Date | 2000 |
Publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ |
Citation | Journal Of Virology, 2000, v. 74 n. 16, p. 7642-7645 How to Cite? |
Abstract | Intestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy. |
Persistent Identifier | http://hdl.handle.net/10722/175813 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seppen, J | en_US |
dc.contributor.author | Barry, SC | en_US |
dc.contributor.author | Klinkspoor, JH | en_US |
dc.contributor.author | Katen, LJ | en_US |
dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Garcia, JV | en_US |
dc.contributor.author | Osborne, WRA | en_US |
dc.date.accessioned | 2012-11-26T09:01:31Z | - |
dc.date.available | 2012-11-26T09:01:31Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Journal Of Virology, 2000, v. 74 n. 16, p. 7642-7645 | en_US |
dc.identifier.issn | 0022-538X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175813 | - |
dc.description.abstract | Intestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | en_US |
dc.relation.ispartof | Journal of Virology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Caco-2 Cells | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Cell Polarity | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epithelial Cells - Virology | en_US |
dc.subject.mesh | Gallbladder - Cytology | en_US |
dc.subject.mesh | Gene Transfer Techniques | en_US |
dc.subject.mesh | Genetic Vectors - Genetics | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intestinal Mucosa - Virology | en_US |
dc.subject.mesh | Lentivirus - Genetics | en_US |
dc.subject.mesh | Membrane Glycoproteins | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Moloney Murine Leukemia Virus - Genetics | en_US |
dc.subject.mesh | Transduction, Genetic | en_US |
dc.subject.mesh | Viral Envelope Proteins - Genetics | en_US |
dc.title | Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1128/JVI.74.16.7642-7645.2000 | en_US |
dc.identifier.pmid | 10906219 | - |
dc.identifier.scopus | eid_2-s2.0-0033865631 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033865631&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 74 | en_US |
dc.identifier.issue | 16 | en_US |
dc.identifier.spage | 7642 | en_US |
dc.identifier.epage | 7645 | en_US |
dc.identifier.isi | WOS:000088342400047 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Seppen, J=6701548547 | en_US |
dc.identifier.scopusauthorid | Barry, SC=7102878821 | en_US |
dc.identifier.scopusauthorid | Klinkspoor, JH=6602590656 | en_US |
dc.identifier.scopusauthorid | Katen, LJ=6508370872 | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Garcia, JV=7406129458 | en_US |
dc.identifier.scopusauthorid | Osborne, WRA=7005020110 | en_US |
dc.identifier.issnl | 0022-538X | - |