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Article: Family-based association tests for quantitative traits using pooled DNA

TitleFamily-based association tests for quantitative traits using pooled DNA
Authors
Bader, JSSham, P
KeywordsAssociation
DNA pooling
Genotyping
Linkage
Quantitative trait locus (QTL)
Single-nucleotide polymorphism (SNP)
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhg
Citation
European Journal Of Human Genetics, 2002, v. 10 n. 12, p. 870-878 How to Cite?
DOI: http://dx.doi.org/10.1038/sj.ejhg.5200893
AbstractInterest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.
Persistent Identifierhttp://hdl.handle.net/10722/175873
ISSN
1018-4813
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.538
ISI Accession Number ID
WOS:000179907100014
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorBader, JSen_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:01:57Z-
dc.date.available2012-11-26T09:01:57Z-
dc.date.issued2002en_US
dc.identifier.citationEuropean Journal Of Human Genetics, 2002, v. 10 n. 12, p. 870-878en_US
dc.identifier.issn1018-4813en_US
dc.identifier.urihttp://hdl.handle.net/10722/175873-
dc.description.abstractInterest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhgen_US
dc.relation.ispartofEuropean Journal of Human Geneticsen_US
dc.subjectAssociation-
dc.subjectDNA pooling-
dc.subjectGenotyping-
dc.subjectLinkage-
dc.subjectQuantitative trait locus (QTL)-
dc.subjectSingle-nucleotide polymorphism (SNP)-
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshDna - Genetics - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshQuantitative Trait Loci - Geneticsen_US
dc.titleFamily-based association tests for quantitative traits using pooled DNAen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.ejhg.5200893en_US
dc.identifier.pmid12461696-
dc.identifier.scopuseid_2-s2.0-0036926785en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036926785&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue12en_US
dc.identifier.spage870en_US
dc.identifier.epage878en_US
dc.identifier.isiWOS:000179907100014-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBader, JS=7201629332en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.issnl1018-4813-

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