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- PMID: 16044171
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Article: Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations
Title | Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations |
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Authors | |
Keywords | 6p Association Dysbindin Dystrobrevin Psychosis |
Issue Date | 2005 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/mp |
Citation | Molecular Psychiatry, 2005, v. 10 n. 11, p. 1037-1044 How to Cite? |
Abstract | The dystrobrevin-binding protein 1 (DTNBP1) gene on chromosome 6p has emerged as a potential susceptibility gene for schizophrenia. Although a number of attempts to replicate the original association finding have been successful, they have not identified any obvious pathogenic variants or a single at risk haplotype common to all populations studied. In the present study we attempted further replication in an independent sample of 638 nuclear families from the Han Chinese population of Sichuan Province, SW China. We also examined 580 Scottish schizophrenic cases and 620 controls. We genotyped 10 single-nucleotide polymorphisms (SNPs) in DTNBP1 that were used in the original report of association, plus rs2619538 (SNP 'A') in the putative promoter region, which has also been associated with schizophrenia. In the Chinese trios we found that two SNPs (P1635 and P1765) were significantly overtransmitted, but with alleles opposite to those reported in the original studies. SNPs P1757 and P1765 formed a common haplotype, which also showed significant overtransmission. In the Scottish cases and controls, no individual markers were significantly associated with schizophrenia. A single haplotype, which included rs2619538 and P1583, and one rare haplotype, composed of P1320 and P1757, were significantly associated with schizophrenia, but no previously reported haplotypes were associated. Based on the data from the Chinese population, our results provide statistical support for DTNBP1 as a susceptibility gene for schizophrenia, albeit with haplotypes different from those of the original study. However, our lack of replication in the Scottish samples also indicates that caution is warranted when evaluating the robustness of the evidence for DTNBP1 as genetic risk factor for schizophrenia. © 2005 Nature Publishing Group All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/175944 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.895 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, T | en_US |
dc.contributor.author | Zhang, F | en_US |
dc.contributor.author | Liu, X | en_US |
dc.contributor.author | Sun, X | en_US |
dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Crombie, C | en_US |
dc.contributor.author | Ma, X | en_US |
dc.contributor.author | Wang, Q | en_US |
dc.contributor.author | Meng, H | en_US |
dc.contributor.author | Deng, W | en_US |
dc.contributor.author | Yates, P | en_US |
dc.contributor.author | Hu, X | en_US |
dc.contributor.author | Walker, N | en_US |
dc.contributor.author | Murray, RM | en_US |
dc.contributor.author | St Clair, D | en_US |
dc.contributor.author | Collier, DA | en_US |
dc.date.accessioned | 2012-11-26T09:02:45Z | - |
dc.date.available | 2012-11-26T09:02:45Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Molecular Psychiatry, 2005, v. 10 n. 11, p. 1037-1044 | en_US |
dc.identifier.issn | 1359-4184 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175944 | - |
dc.description.abstract | The dystrobrevin-binding protein 1 (DTNBP1) gene on chromosome 6p has emerged as a potential susceptibility gene for schizophrenia. Although a number of attempts to replicate the original association finding have been successful, they have not identified any obvious pathogenic variants or a single at risk haplotype common to all populations studied. In the present study we attempted further replication in an independent sample of 638 nuclear families from the Han Chinese population of Sichuan Province, SW China. We also examined 580 Scottish schizophrenic cases and 620 controls. We genotyped 10 single-nucleotide polymorphisms (SNPs) in DTNBP1 that were used in the original report of association, plus rs2619538 (SNP 'A') in the putative promoter region, which has also been associated with schizophrenia. In the Chinese trios we found that two SNPs (P1635 and P1765) were significantly overtransmitted, but with alleles opposite to those reported in the original studies. SNPs P1757 and P1765 formed a common haplotype, which also showed significant overtransmission. In the Scottish cases and controls, no individual markers were significantly associated with schizophrenia. A single haplotype, which included rs2619538 and P1583, and one rare haplotype, composed of P1320 and P1757, were significantly associated with schizophrenia, but no previously reported haplotypes were associated. Based on the data from the Chinese population, our results provide statistical support for DTNBP1 as a susceptibility gene for schizophrenia, albeit with haplotypes different from those of the original study. However, our lack of replication in the Scottish samples also indicates that caution is warranted when evaluating the robustness of the evidence for DTNBP1 as genetic risk factor for schizophrenia. © 2005 Nature Publishing Group All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/mp | en_US |
dc.relation.ispartof | Molecular Psychiatry | en_US |
dc.subject | 6p | - |
dc.subject | Association | - |
dc.subject | Dysbindin | - |
dc.subject | Dystrobrevin | - |
dc.subject | Psychosis | - |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Carrier Proteins - Genetics | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | China | en_US |
dc.subject.mesh | Chromosomes, Human, Pair 6 - Genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Markers | en_US |
dc.subject.mesh | Haplotypes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Linkage Disequilibrium | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Schizophrenia - Genetics | en_US |
dc.subject.mesh | Scotland | en_US |
dc.title | Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/sj.mp.4001718 | en_US |
dc.identifier.pmid | 16044171 | - |
dc.identifier.scopus | eid_2-s2.0-27544484881 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-27544484881&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 1037 | en_US |
dc.identifier.epage | 1044 | en_US |
dc.identifier.isi | WOS:000232833000010 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Li, T=36072008200 | en_US |
dc.identifier.scopusauthorid | Zhang, F=24465951900 | en_US |
dc.identifier.scopusauthorid | Liu, X=7409286408 | en_US |
dc.identifier.scopusauthorid | Sun, X=7405624871 | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Crombie, C=12240136900 | en_US |
dc.identifier.scopusauthorid | Ma, X=35354066000 | en_US |
dc.identifier.scopusauthorid | Wang, Q=7406916913 | en_US |
dc.identifier.scopusauthorid | Meng, H=9133658800 | en_US |
dc.identifier.scopusauthorid | Deng, W=7202222559 | en_US |
dc.identifier.scopusauthorid | Yates, P=8921964400 | en_US |
dc.identifier.scopusauthorid | Hu, X=7404709241 | en_US |
dc.identifier.scopusauthorid | Walker, N=7201514664 | en_US |
dc.identifier.scopusauthorid | Murray, RM=35406239400 | en_US |
dc.identifier.scopusauthorid | St Clair, D=35354078200 | en_US |
dc.identifier.scopusauthorid | Collier, DA=26642980600 | en_US |
dc.identifier.citeulike | 265038 | - |
dc.identifier.issnl | 1359-4184 | - |