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Conference Paper: Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data

TitleComparison of GENEHUNTER and MFLINK for analysis of COGA linkage data
Authors
Curtis, DZhao, JHSham, PC
KeywordsModel-free
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
Genetic Epidemiology, 1999, v. 17 SUPPL. 1, p. S115-S120 How to Cite?
AbstractWe compared the NPL(ALL) statistic from GENEHUNTER with two-point and three-point MALODs and MFLODs from MFLINK for all autosomal markers in the Collaborative Study on the Genetics of Alcoholism (COGA) data set. In general MFLINK produced more significant results than GENEHUNTER and implicated two regions containing candidate genes (ADH3 and DRD2). Many regions of interest identified in other studies reported at this workshop produced MALODs significant at p ≤ 0.05, but these would not have been picked up by GENEHUNTER unless a less significant threshold were used.
Persistent Identifierhttp://hdl.handle.net/10722/176085
ISSN
0741-0395
2023 Impact Factor: 1.7
2023 SCImago Journal Rankings: 0.977
ISI Accession Number ID
WOS:000083945800018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorCurtis, Den_US
dc.contributor.authorZhao, JHen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:05:31Z-
dc.date.available2012-11-26T09:05:31Z-
dc.date.issued1999en_US
dc.identifier.citationGenetic Epidemiology, 1999, v. 17 SUPPL. 1, p. S115-S120en_US
dc.identifier.issn0741-0395en_US
dc.identifier.urihttp://hdl.handle.net/10722/176085-
dc.description.abstractWe compared the NPL(ALL) statistic from GENEHUNTER with two-point and three-point MALODs and MFLODs from MFLINK for all autosomal markers in the Collaborative Study on the Genetics of Alcoholism (COGA) data set. In general MFLINK produced more significant results than GENEHUNTER and implicated two regions containing candidate genes (ADH3 and DRD2). Many regions of interest identified in other studies reported at this workshop produced MALODs significant at p ≤ 0.05, but these would not have been picked up by GENEHUNTER unless a less significant threshold were used.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_US
dc.relation.ispartofGenetic Epidemiologyen_US
dc.subjectModel-free-
dc.subject.meshAlcoholism - Geneticsen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshSoftwareen_US
dc.titleComparison of GENEHUNTER and MFLINK for analysis of COGA linkage dataen_US
dc.typeConference_Paperen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10597422-
dc.identifier.scopuseid_2-s2.0-0003250482en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0003250482&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spageS115en_US
dc.identifier.epageS120en_US
dc.identifier.isiWOS:000083945800018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCurtis, D=14633020700en_US
dc.identifier.scopusauthoridZhao, JH=7410311266en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.issnl0741-0395-

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