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- Publisher Website: 10.1016/0024-3205(84)90281-9
- Scopus: eid_2-s2.0-0021274898
- PMID: 6233467
- WOS: WOS:A1984ST14300003
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Article: 5-Hydroxytryptamine: A modulator of food composition but not quantity?
Title | 5-Hydroxytryptamine: A modulator of food composition but not quantity? |
---|---|
Authors | |
Issue Date | 1984 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 1984, v. 34 n. 25, p. 2453-2460 How to Cite? |
Abstract | After a meal of protein, in contrast to a meal of carbohydrate (CHO) at 1915 hr, rats allowed to choose from high carbohydrate and high protein diets during 2000-2100 hr prefer CHO (1). Thus the hypothesis that this regulation of macronutrient selection involves brain 5-hydroxytryptamine (5-HT) metabolism was tested. Compared to three baseline days during which rats (250-300 g) consumed 1 g CHO, rats fed tryptophan (TRP, 5-HT precursor; 15 mg in 1 g CHO) selected meals higher in protein concentration (35.4% vs 46.6%, F (1,12)=20.05, p<0.001) from 10% and 60% casein diets during 2000-2100 hr. Associated with the higher protein selection was an elevated brain 5-HT turnover in rats killed 30 minutes after consuming CHO + TRP. Pretreating rats with p-chlorophenylalanine, an inhibitor of TRP hydroxylase, blocked this effect of TRP (36.3% vs 37.0%). Fenfluramine (1 and 2 mg/kg i.p. at 1945 hr), which transiently enhances neuronal 5-HT release, increased the rat's relative preference for protein from 28.8% to 37.5% (2 mg/kg, t=3.21, p<0.025) during 200-2100 hr. These rats, also exhibited a selective preference for CHO between 3-12 hrs post injection which paralleled the known subsequent depletion of 5-HT by fenfluramine. We conclude that the relative proportion of protein and carbohydrate selected in a meal is controlled, at lest in part, by prior food effects on brain 5-HT metabolism. |
Persistent Identifier | http://hdl.handle.net/10722/178425 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, ETS | en_US |
dc.contributor.author | Anderson, GH | en_US |
dc.date.accessioned | 2012-12-19T09:47:38Z | - |
dc.date.available | 2012-12-19T09:47:38Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | Life Sciences, 1984, v. 34 n. 25, p. 2453-2460 | en_US |
dc.identifier.issn | 0024-3205 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178425 | - |
dc.description.abstract | After a meal of protein, in contrast to a meal of carbohydrate (CHO) at 1915 hr, rats allowed to choose from high carbohydrate and high protein diets during 2000-2100 hr prefer CHO (1). Thus the hypothesis that this regulation of macronutrient selection involves brain 5-hydroxytryptamine (5-HT) metabolism was tested. Compared to three baseline days during which rats (250-300 g) consumed 1 g CHO, rats fed tryptophan (TRP, 5-HT precursor; 15 mg in 1 g CHO) selected meals higher in protein concentration (35.4% vs 46.6%, F (1,12)=20.05, p<0.001) from 10% and 60% casein diets during 2000-2100 hr. Associated with the higher protein selection was an elevated brain 5-HT turnover in rats killed 30 minutes after consuming CHO + TRP. Pretreating rats with p-chlorophenylalanine, an inhibitor of TRP hydroxylase, blocked this effect of TRP (36.3% vs 37.0%). Fenfluramine (1 and 2 mg/kg i.p. at 1945 hr), which transiently enhances neuronal 5-HT release, increased the rat's relative preference for protein from 28.8% to 37.5% (2 mg/kg, t=3.21, p<0.025) during 200-2100 hr. These rats, also exhibited a selective preference for CHO between 3-12 hrs post injection which paralleled the known subsequent depletion of 5-HT by fenfluramine. We conclude that the relative proportion of protein and carbohydrate selected in a meal is controlled, at lest in part, by prior food effects on brain 5-HT metabolism. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | en_US |
dc.relation.ispartof | Life Sciences | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Brain Chemistry - Drug Effects | en_US |
dc.subject.mesh | Dietary Carbohydrates | en_US |
dc.subject.mesh | Dietary Proteins | en_US |
dc.subject.mesh | Fenclonine - Pharmacology | en_US |
dc.subject.mesh | Fenfluramine - Pharmacology | en_US |
dc.subject.mesh | Food Preferences | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Serotonin - Analysis - Physiology | en_US |
dc.subject.mesh | Tryptophan - Pharmacology | en_US |
dc.title | 5-Hydroxytryptamine: A modulator of food composition but not quantity? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, ETS: etsli@hku.hk | en_US |
dc.identifier.authority | Li, ETS=rp00737 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0024-3205(84)90281-9 | en_US |
dc.identifier.pmid | 6233467 | - |
dc.identifier.scopus | eid_2-s2.0-0021274898 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 25 | en_US |
dc.identifier.spage | 2453 | en_US |
dc.identifier.epage | 2460 | en_US |
dc.identifier.isi | WOS:A1984ST14300003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, ETS=14018169600 | en_US |
dc.identifier.scopusauthorid | Anderson, GH=7404223441 | en_US |
dc.identifier.issnl | 0024-3205 | - |