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- Publisher Website: 10.1016/0031-9384(87)90201-0
- Scopus: eid_2-s2.0-0023222026
- PMID: 3628523
- WOS: WOS:A1987H760000004
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Article: Food intake and selection after peripheral tryptophan
Title | Food intake and selection after peripheral tryptophan |
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Authors | |
Keywords | Carbohydrate intake Protein intake Self-selection Tryptophan |
Issue Date | 1987 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/physbeh |
Citation | Physiology And Behavior, 1987, v. 40 n. 2, p. 155-163 How to Cite? |
Abstract | Two studies investigated the effects of peripheral (IP) administration of the dietary indispensible amino accid tryptophan, on food intake and macronutrient selection in rats adapted to a 12 hr nocturnal feeding period and a choice of 10% and 60% casein diets, In a dose-response study (35, 55, 75, 95, 115 mg/kg), the threshold dose of 75 mg/kg produced a significant reduction in total food intake (3.6 to 2.3 g, p<0.05) during the first hour of feeding. The reduction in carbohydrate intake (2.1 vs. 1.2 g, p<0.05) was greater than that for protein intake (1.6 vs. 1.1 g, p<0.05). Twelve hr total food intake was also decreased (20.9 to 19.5 g, p<0.05) and this was attributable to decreased carbohydrate intake (13.2 to 11.8 g, p<0.05).In a second study designed to determine if tryptophan's effects were mediated by the central nervous system, brain tryptophan uptake was blocked by co-injecting valine with tryptophan. The significant reduction in first hour total food intake by tryptophan was not prevented by co-injection of an equal quantity of valine (3.5 to 1.8 g, p<0.05). Again the suppression of carbohydrate intake (2.0 to 0.9 g, p<0.05) was greater than that for protein intake (1.5 to 0.9 g, p< 0.05). This dose of valine significantly reduced brain tryptophan uptake by 16% (21.3 to 17.8μg/g, p<0.05) and when administered alone did not affect first hour total food intake (3.1 vs 3.2 g), A higher dose of valine (300 mg/kg) procuced a larger decrease in brain tryptophan (15.9 to 11.7 μg/g, p<0.05), but when administered alone also significantly decreased food intake (2.9 to 0.7 g, p<0.05). Thus the site and mechanism of action for tryptophan's effects could not be elucidated. It was concluded that intraperitoneal administration of tryptophan suppresses total food intake with a small but sinificantly greater effect on carbohydrate intake compared to protein intake. |
Persistent Identifier | http://hdl.handle.net/10722/178458 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.783 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Morris, P | en_US |
dc.contributor.author | Li, ETS | en_US |
dc.contributor.author | Macmillan, ML | en_US |
dc.contributor.author | Anderson, GH | en_US |
dc.date.accessioned | 2012-12-19T09:47:48Z | - |
dc.date.available | 2012-12-19T09:47:48Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Physiology And Behavior, 1987, v. 40 n. 2, p. 155-163 | en_US |
dc.identifier.issn | 0031-9384 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178458 | - |
dc.description.abstract | Two studies investigated the effects of peripheral (IP) administration of the dietary indispensible amino accid tryptophan, on food intake and macronutrient selection in rats adapted to a 12 hr nocturnal feeding period and a choice of 10% and 60% casein diets, In a dose-response study (35, 55, 75, 95, 115 mg/kg), the threshold dose of 75 mg/kg produced a significant reduction in total food intake (3.6 to 2.3 g, p<0.05) during the first hour of feeding. The reduction in carbohydrate intake (2.1 vs. 1.2 g, p<0.05) was greater than that for protein intake (1.6 vs. 1.1 g, p<0.05). Twelve hr total food intake was also decreased (20.9 to 19.5 g, p<0.05) and this was attributable to decreased carbohydrate intake (13.2 to 11.8 g, p<0.05).In a second study designed to determine if tryptophan's effects were mediated by the central nervous system, brain tryptophan uptake was blocked by co-injecting valine with tryptophan. The significant reduction in first hour total food intake by tryptophan was not prevented by co-injection of an equal quantity of valine (3.5 to 1.8 g, p<0.05). Again the suppression of carbohydrate intake (2.0 to 0.9 g, p<0.05) was greater than that for protein intake (1.5 to 0.9 g, p< 0.05). This dose of valine significantly reduced brain tryptophan uptake by 16% (21.3 to 17.8μg/g, p<0.05) and when administered alone did not affect first hour total food intake (3.1 vs 3.2 g), A higher dose of valine (300 mg/kg) procuced a larger decrease in brain tryptophan (15.9 to 11.7 μg/g, p<0.05), but when administered alone also significantly decreased food intake (2.9 to 0.7 g, p<0.05). Thus the site and mechanism of action for tryptophan's effects could not be elucidated. It was concluded that intraperitoneal administration of tryptophan suppresses total food intake with a small but sinificantly greater effect on carbohydrate intake compared to protein intake. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/physbeh | en_US |
dc.relation.ispartof | Physiology and Behavior | en_US |
dc.subject | Carbohydrate intake | - |
dc.subject | Protein intake | - |
dc.subject | Self-selection | - |
dc.subject | Tryptophan | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Brain - Metabolism | en_US |
dc.subject.mesh | Dietary Carbohydrates - Metabolism | en_US |
dc.subject.mesh | Dietary Proteins - Metabolism | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Feeding Behavior - Drug Effects | en_US |
dc.subject.mesh | Food Preferences - Drug Effects | en_US |
dc.subject.mesh | Injections, Intraperitoneal | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.subject.mesh | Tryptophan - Administration & Dosage - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Valine - Administration & Dosage - Pharmacology | en_US |
dc.title | Food intake and selection after peripheral tryptophan | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, ETS: etsli@hku.hk | en_US |
dc.identifier.authority | Li, ETS=rp00737 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0031-9384(87)90201-0 | - |
dc.identifier.pmid | 3628523 | - |
dc.identifier.scopus | eid_2-s2.0-0023222026 | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 155 | en_US |
dc.identifier.epage | 163 | en_US |
dc.identifier.isi | WOS:A1987H760000004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Morris, P=16033976800 | en_US |
dc.identifier.scopusauthorid | Li, ETS=14018169600 | en_US |
dc.identifier.scopusauthorid | MacMillan, ML=35802897900 | en_US |
dc.identifier.scopusauthorid | Anderson, GH=7404223441 | en_US |
dc.identifier.issnl | 0031-9384 | - |