File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin
Title | Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin |
---|---|
Authors | |
Keywords | Acas570 Lipid Hydroperoxide Low-Density Lipoprotein Mitochondrial Membrane Potential Peritoneal Macrophage Polysaccharide Krestin (Psk) |
Issue Date | 1996 |
Publisher | Chapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html |
Citation | Medical Science Research, 1996, v. 24 n. 10, p. 715-717 How to Cite? |
Abstract | Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein (Ox-LDL) and the protective effect of a protein-bound polysaccharide krestin (PSK) from Coriolus versicolor were observed by measuring mitochondrial membrane potential according to fluorescence intensity using an ACAS570. Ox-LDL incubated with macrophages caused a decrease in mitochondrial membrane potential- an indicator of cytotoxicity. As compared with Ox-LDL, native LDL had no effect and acetylated LDL(AC-LDL) had a lesser effect on mitochondrial membrane potential. PSK, a non-specific immune enhancer intraperitoneally injected into mice, protected mitochondria of macrophage from the injury caused by Ox-LDL. The mechanism of injury may be related to the accumulation of lipid hydroperoxides (LPO) in macrophages and PSK protected cells by decreasing cellular LPO. |
Persistent Identifier | http://hdl.handle.net/10722/178585 |
ISSN | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, SX | en_US |
dc.contributor.author | Zhou, M | en_US |
dc.contributor.author | Chert, Y | en_US |
dc.contributor.author | Wen, WY | en_US |
dc.contributor.author | Wan, J | en_US |
dc.date.accessioned | 2012-12-19T09:48:30Z | - |
dc.date.available | 2012-12-19T09:48:30Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Medical Science Research, 1996, v. 24 n. 10, p. 715-717 | en_US |
dc.identifier.issn | 0269-8951 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178585 | - |
dc.description.abstract | Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein (Ox-LDL) and the protective effect of a protein-bound polysaccharide krestin (PSK) from Coriolus versicolor were observed by measuring mitochondrial membrane potential according to fluorescence intensity using an ACAS570. Ox-LDL incubated with macrophages caused a decrease in mitochondrial membrane potential- an indicator of cytotoxicity. As compared with Ox-LDL, native LDL had no effect and acetylated LDL(AC-LDL) had a lesser effect on mitochondrial membrane potential. PSK, a non-specific immune enhancer intraperitoneally injected into mice, protected mitochondria of macrophage from the injury caused by Ox-LDL. The mechanism of injury may be related to the accumulation of lipid hydroperoxides (LPO) in macrophages and PSK protected cells by decreasing cellular LPO. | en_US |
dc.language | eng | en_US |
dc.publisher | Chapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html | en_US |
dc.relation.ispartof | Medical Science Research | en_US |
dc.subject | Acas570 | en_US |
dc.subject | Lipid Hydroperoxide | en_US |
dc.subject | Low-Density Lipoprotein | en_US |
dc.subject | Mitochondrial Membrane Potential | en_US |
dc.subject | Peritoneal Macrophage | en_US |
dc.subject | Polysaccharide Krestin (Psk) | en_US |
dc.title | Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wan, J: jmfwan@hku.hk | en_US |
dc.identifier.authority | Wan, J=rp00798 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-0029854740 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029854740&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 715 | en_US |
dc.identifier.epage | 717 | en_US |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Liu, SX=7409463469 | en_US |
dc.identifier.scopusauthorid | Zhou, M=7403506134 | en_US |
dc.identifier.scopusauthorid | Chert, Y=14918992500 | en_US |
dc.identifier.scopusauthorid | Wen, WY=7102170594 | en_US |
dc.identifier.scopusauthorid | Wan, J=8930305000 | en_US |
dc.identifier.issnl | 0269-8951 | - |