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- Publisher Website: 10.1021/jf990082e
- Scopus: eid_2-s2.0-0032854044
- PMID: 10552618
- WOS: WOS:000082128700024
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Article: Thermal degradation of sulforaphane in aqueous solution
Title | Thermal degradation of sulforaphane in aqueous solution |
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Authors | |
Keywords | Isothiocyante N,N'- di(methylsulfinyl)butyl thiourea Sulforaphane Thermal decomposition |
Issue Date | 1999 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau |
Citation | Journal Of Agricultural And Food Chemistry, 1999, v. 47 n. 8, p. 3121-3123 How to Cite? |
Abstract | Sulforaphane, a cancer chemopreventive agent identified from broccoli, was degraded in an aqueous solution at 50 and 100 °C. The reaction mixtures were extracted with methylene chloride and analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Dimethyl disulfide, S- methyl methylthiosulfinate, S-methyl methylthiosulfonate, methyl (methylthio)methyl disulfide, 1,2,4-trithiolane, 4-isothiocyanato-1- (methylthio)-1-butene, and 3-butenyl isothiocyanate were identified as volatile decomposition products. After methylene chloride extraction, the aqueous layer was dried and silica gel column chromatography was used to separate and purify the nonvolatile decomposition products. The major thermal degradation compound was determined by 1H NMR, 13C NMR, and FAB-MS as N,N'-di(4-methylsulfinyl)butyl thiourea. A possible mechanism for the formation of these products is proposed. |
Persistent Identifier | http://hdl.handle.net/10722/178656 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.114 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin, Y | en_US |
dc.contributor.author | Wang, M | en_US |
dc.contributor.author | Rosen, RT | en_US |
dc.contributor.author | Ho, CT | en_US |
dc.date.accessioned | 2012-12-19T09:48:59Z | - |
dc.date.available | 2012-12-19T09:48:59Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Journal Of Agricultural And Food Chemistry, 1999, v. 47 n. 8, p. 3121-3123 | en_US |
dc.identifier.issn | 0021-8561 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178656 | - |
dc.description.abstract | Sulforaphane, a cancer chemopreventive agent identified from broccoli, was degraded in an aqueous solution at 50 and 100 °C. The reaction mixtures were extracted with methylene chloride and analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Dimethyl disulfide, S- methyl methylthiosulfinate, S-methyl methylthiosulfonate, methyl (methylthio)methyl disulfide, 1,2,4-trithiolane, 4-isothiocyanato-1- (methylthio)-1-butene, and 3-butenyl isothiocyanate were identified as volatile decomposition products. After methylene chloride extraction, the aqueous layer was dried and silica gel column chromatography was used to separate and purify the nonvolatile decomposition products. The major thermal degradation compound was determined by 1H NMR, 13C NMR, and FAB-MS as N,N'-di(4-methylsulfinyl)butyl thiourea. A possible mechanism for the formation of these products is proposed. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau | en_US |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | en_US |
dc.subject | Isothiocyante | - |
dc.subject | N,N'- di(methylsulfinyl)butyl thiourea | - |
dc.subject | Sulforaphane | - |
dc.subject | Thermal decomposition | - |
dc.subject.mesh | Anticarcinogenic Agents - Chemistry | en_US |
dc.subject.mesh | Brassica | en_US |
dc.subject.mesh | Cooking | en_US |
dc.subject.mesh | Hot Temperature | en_US |
dc.subject.mesh | Magnetic Resonance Spectroscopy | en_US |
dc.subject.mesh | Solutions | en_US |
dc.subject.mesh | Spectrometry, Mass, Fast Atom Bombardment | en_US |
dc.subject.mesh | Thiocyanates - Chemistry | en_US |
dc.subject.mesh | Water | en_US |
dc.title | Thermal degradation of sulforaphane in aqueous solution | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wang, M: mfwang@hku.hk | en_US |
dc.identifier.authority | Wang, M=rp00800 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/jf990082e | en_US |
dc.identifier.pmid | 10552618 | - |
dc.identifier.scopus | eid_2-s2.0-0032854044 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032854044&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 3121 | en_US |
dc.identifier.epage | 3123 | en_US |
dc.identifier.isi | WOS:000082128700024 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Jin, Y=55215771400 | en_US |
dc.identifier.scopusauthorid | Wang, M=7406691844 | en_US |
dc.identifier.scopusauthorid | Rosen, RT=7202895150 | en_US |
dc.identifier.scopusauthorid | Ho, CT=7404652573 | en_US |
dc.identifier.issnl | 0021-8561 | - |