File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S0304-3835(99)00224-4
- Scopus: eid_2-s2.0-0032886232
- PMID: 10530765
- WOS: WOS:000082705700003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression
Title | Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression |
---|---|
Authors | |
Keywords | Apoptosis Bcl-2 Cell cycle Eicosapentaenoic acid Flow cytometry Human leukemic cells |
Issue Date | 1999 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet |
Citation | Cancer Letters, 1999, v. 145 n. 1-2, p. 17-27 How to Cite? |
Abstract | Dietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid (EPA) was found to inhibit proliferation of human leukemic HL-60 and K-562 cells in vitro. EPA arrested cell cycle progression at G0/G1 phase, and induced necrosis in both HL-60 and K-562 cells. However, EPA induced apoptosis only in HL-60 but not K-562 cells. Also, bcl-2 protein expression was downregulated in much greater extent than that of bax showing that depression of bcl-2 might be an important step during the EPA-induced apoptosis in HL-60 cells. |
Persistent Identifier | http://hdl.handle.net/10722/178660 |
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.595 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chiu, LCM | en_US |
dc.contributor.author | Wan, JMF | en_US |
dc.date.accessioned | 2012-12-19T09:49:00Z | - |
dc.date.available | 2012-12-19T09:49:00Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Cancer Letters, 1999, v. 145 n. 1-2, p. 17-27 | en_US |
dc.identifier.issn | 0304-3835 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178660 | - |
dc.description.abstract | Dietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid (EPA) was found to inhibit proliferation of human leukemic HL-60 and K-562 cells in vitro. EPA arrested cell cycle progression at G0/G1 phase, and induced necrosis in both HL-60 and K-562 cells. However, EPA induced apoptosis only in HL-60 but not K-562 cells. Also, bcl-2 protein expression was downregulated in much greater extent than that of bax showing that depression of bcl-2 might be an important step during the EPA-induced apoptosis in HL-60 cells. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet | en_US |
dc.relation.ispartof | Cancer Letters | en_US |
dc.subject | Apoptosis | - |
dc.subject | Bcl-2 | - |
dc.subject | Cell cycle | - |
dc.subject | Eicosapentaenoic acid | - |
dc.subject | Flow cytometry | - |
dc.subject | Human leukemic cells | - |
dc.subject.mesh | Apoptosis - Drug Effects | en_US |
dc.subject.mesh | Down-Regulation | en_US |
dc.subject.mesh | Drug Screening Assays, Antitumor | en_US |
dc.subject.mesh | Eicosapentaenoic Acid - Pharmacology | en_US |
dc.subject.mesh | Flow Cytometry | en_US |
dc.subject.mesh | G0 Phase - Drug Effects | en_US |
dc.subject.mesh | G1 Phase - Drug Effects | en_US |
dc.subject.mesh | Hl-60 Cells | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Leukemia, Myelogenous, Chronic, Bcr-Abl Positive - Drug Therapy - Pathology | en_US |
dc.subject.mesh | Leukemia, Promyelocytic, Acute - Drug Therapy - Pathology | en_US |
dc.subject.mesh | Proto-Oncogene Proteins C-Bcl-2 - Biosynthesis | en_US |
dc.subject.mesh | Tumor Cells, Cultured | en_US |
dc.title | Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wan, JMF: jmfwan@hku.hk | en_US |
dc.identifier.authority | Wan, JMF=rp00798 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0304-3835(99)00224-4 | en_US |
dc.identifier.pmid | 10530765 | - |
dc.identifier.scopus | eid_2-s2.0-0032886232 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032886232&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 145 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 17 | en_US |
dc.identifier.epage | 27 | en_US |
dc.identifier.isi | WOS:000082705700003 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Chiu, LCM=7103129041 | en_US |
dc.identifier.scopusauthorid | Wan, JMF=8930305000 | en_US |
dc.identifier.issnl | 0304-3835 | - |