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- Publisher Website: 10.1016/S0045-6535(00)00297-6
- Scopus: eid_2-s2.0-0034963408
- PMID: 11459135
- WOS: WOS:000169652100002
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Article: Metallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide
Title | Metallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide |
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Authors | |
Keywords | Antioxidant Biomarker Metal binding protein Metallothionein Oxidative stress |
Issue Date | 2001 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere |
Citation | Chemosphere, 2001, v. 44 n. 3, p. 321-325 How to Cite? |
Abstract | It has been suggested that metallothionein (MT) not only can regulate essential metals and detoxify toxic metals, but that MT can also play a significant role as an antioxidant and can be induced by oxidative stresses other than metals. This study is aimed at investigating the effect of hydrogen peroxide (H2O2), and the combined effect of H2O2 and cadmium (Cd) on MT induction and condition index (CI) in dogwhelks Nucella lapillus. Adult male dogwhelks (27 ± 1 mm in shell length) were exposed for 20 days to (1) control (filtered natural seawater only); (2), 0.50 ppm Cd; (3) 2.0 ppm H2O2 + 0.50 ppm Cd; (4) 1.0 ppm H2O2 + 0.25 ppm Cd; (5) 2.0 ppm H2O2; (6) 1000 ppm H2O2 or (7) 1000 ppm H2O2 + 0.50 ppm Cd. The concentration of MT in the Leiblein gland of N. lapillus was quantified using the silver saturation method. MT or MT-like proteins in the animals were induced by Cd (0.5 ppm), H2O2 (2.0 ppm) or Cd + H2O2, indicating that MT in this gastropod species can be induced by either metal or oxidative stresses. Exposure to high H2O2 (1000 ppm) alone or combined with Cd, and exposure to Cd (0.50 ppm) or H2O2 (2.0 ppm), resulted in significant weight loss, indicated by a reduction of CI. However, CIs of groups (3) and (4) were similar to that of the control suggesting that Cd antagonistically reduces toxicity caused by H2O2 since Cd-induced MT may have a protective function against hydroxyl radicals. © 2001 Elsevier Science Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/178732 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 1.806 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Leung, KMY | en_US |
dc.contributor.author | Furness, RW | en_US |
dc.date.accessioned | 2012-12-19T09:49:22Z | - |
dc.date.available | 2012-12-19T09:49:22Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Chemosphere, 2001, v. 44 n. 3, p. 321-325 | en_US |
dc.identifier.issn | 0045-6535 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178732 | - |
dc.description.abstract | It has been suggested that metallothionein (MT) not only can regulate essential metals and detoxify toxic metals, but that MT can also play a significant role as an antioxidant and can be induced by oxidative stresses other than metals. This study is aimed at investigating the effect of hydrogen peroxide (H2O2), and the combined effect of H2O2 and cadmium (Cd) on MT induction and condition index (CI) in dogwhelks Nucella lapillus. Adult male dogwhelks (27 ± 1 mm in shell length) were exposed for 20 days to (1) control (filtered natural seawater only); (2), 0.50 ppm Cd; (3) 2.0 ppm H2O2 + 0.50 ppm Cd; (4) 1.0 ppm H2O2 + 0.25 ppm Cd; (5) 2.0 ppm H2O2; (6) 1000 ppm H2O2 or (7) 1000 ppm H2O2 + 0.50 ppm Cd. The concentration of MT in the Leiblein gland of N. lapillus was quantified using the silver saturation method. MT or MT-like proteins in the animals were induced by Cd (0.5 ppm), H2O2 (2.0 ppm) or Cd + H2O2, indicating that MT in this gastropod species can be induced by either metal or oxidative stresses. Exposure to high H2O2 (1000 ppm) alone or combined with Cd, and exposure to Cd (0.50 ppm) or H2O2 (2.0 ppm), resulted in significant weight loss, indicated by a reduction of CI. However, CIs of groups (3) and (4) were similar to that of the control suggesting that Cd antagonistically reduces toxicity caused by H2O2 since Cd-induced MT may have a protective function against hydroxyl radicals. © 2001 Elsevier Science Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere | en_US |
dc.relation.ispartof | Chemosphere | en_US |
dc.subject | Antioxidant | - |
dc.subject | Biomarker | - |
dc.subject | Metal binding protein | - |
dc.subject | Metallothionein | - |
dc.subject | Oxidative stress | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Markers - Analysis | en_US |
dc.subject.mesh | Cadmium - Adverse Effects | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Environmental Exposure | en_US |
dc.subject.mesh | Hydrogen Peroxide - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Metallothionein - Chemical Synthesis | en_US |
dc.subject.mesh | Mollusca - Physiology | en_US |
dc.subject.mesh | Oxidants - Pharmacology | en_US |
dc.subject.mesh | Oxidation-Reduction | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.subject.mesh | Water Pollutants - Adverse Effects | en_US |
dc.title | Metallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, KMY: kmyleung@hku.hk | en_US |
dc.identifier.authority | Leung, KMY=rp00733 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0045-6535(00)00297-6 | en_US |
dc.identifier.pmid | 11459135 | - |
dc.identifier.scopus | eid_2-s2.0-0034963408 | en_US |
dc.identifier.hkuros | 65778 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034963408&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 321 | en_US |
dc.identifier.epage | 325 | en_US |
dc.identifier.isi | WOS:000169652100002 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Leung, KMY=7401860738 | en_US |
dc.identifier.scopusauthorid | Furness, RW=7103164978 | en_US |
dc.identifier.issnl | 0045-6535 | - |