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- PMID: 11720534
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Article: Furanosesquiterpenoids of Commiphora myrrha
Title | Furanosesquiterpenoids of Commiphora myrrha |
---|---|
Authors | |
Issue Date | 2001 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnp |
Citation | Journal Of Natural Products, 2001, v. 64 n. 11, p. 1460-1462 How to Cite? |
Abstract | An investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay. |
Persistent Identifier | http://hdl.handle.net/10722/178744 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.802 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhu, N | en_US |
dc.contributor.author | Kikuzaki, H | en_US |
dc.contributor.author | Sheng, S | en_US |
dc.contributor.author | Sang, S | en_US |
dc.contributor.author | Rafi, MM | en_US |
dc.contributor.author | Wang, M | en_US |
dc.contributor.author | Nakatani, N | en_US |
dc.contributor.author | Dipaola, RS | en_US |
dc.contributor.author | Rosen, RT | en_US |
dc.contributor.author | Ho, CT | en_US |
dc.date.accessioned | 2012-12-19T09:49:27Z | - |
dc.date.available | 2012-12-19T09:49:27Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Journal Of Natural Products, 2001, v. 64 n. 11, p. 1460-1462 | en_US |
dc.identifier.issn | 0163-3864 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178744 | - |
dc.description.abstract | An investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnp | en_US |
dc.relation.ispartof | Journal of Natural Products | en_US |
dc.subject.mesh | Antineoplastic Agents, Phytogenic - Chemistry - Isolation & Purification - Pharmacology | en_US |
dc.subject.mesh | Breast Neoplasms | en_US |
dc.subject.mesh | Burseraceae - Chemistry | en_US |
dc.subject.mesh | Chromatography, Thin Layer | en_US |
dc.subject.mesh | Drugs, Chinese Herbal - Chemistry - Isolation & Purification - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Molecular Conformation | en_US |
dc.subject.mesh | Molecular Structure | en_US |
dc.subject.mesh | Nuclear Magnetic Resonance, Biomolecular | en_US |
dc.subject.mesh | Plants, Medicinal - Chemistry | en_US |
dc.subject.mesh | Sesquiterpenes - Chemistry - Isolation & Purification - Pharmacology | en_US |
dc.subject.mesh | Sesquiterpenes, Germacrane | en_US |
dc.subject.mesh | Stereoisomerism | en_US |
dc.subject.mesh | Tumor Cells, Cultured - Drug Effects | en_US |
dc.title | Furanosesquiterpenoids of Commiphora myrrha | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wang, M: mfwang@hku.hk | en_US |
dc.identifier.authority | Wang, M=rp00800 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/np010072j | en_US |
dc.identifier.pmid | 11720534 | - |
dc.identifier.scopus | eid_2-s2.0-0035195802 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035195802&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 1460 | en_US |
dc.identifier.epage | 1462 | en_US |
dc.identifier.isi | WOS:000172496200017 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhu, N=7201449552 | en_US |
dc.identifier.scopusauthorid | Kikuzaki, H=7003452974 | en_US |
dc.identifier.scopusauthorid | Sheng, S=7102347594 | en_US |
dc.identifier.scopusauthorid | Sang, S=7006277967 | en_US |
dc.identifier.scopusauthorid | Rafi, MM=7005112935 | en_US |
dc.identifier.scopusauthorid | Wang, M=7406691844 | en_US |
dc.identifier.scopusauthorid | Nakatani, N=7102434865 | en_US |
dc.identifier.scopusauthorid | DiPaola, RS=7004220521 | en_US |
dc.identifier.scopusauthorid | Rosen, RT=7202895150 | en_US |
dc.identifier.scopusauthorid | Ho, CT=7404652573 | en_US |
dc.identifier.issnl | 0163-3864 | - |