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- Publisher Website: 10.1002/ptr.1172
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- PMID: 12748978
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Article: Short-term control of capsaicin on blood and oxidative stress of rats in vivo
Title | Short-term control of capsaicin on blood and oxidative stress of rats in vivo |
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Authors | |
Keywords | Antioxidant Capsaicin LDL MC-FAN |
Issue Date | 2003 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 |
Citation | Phytotherapy Research, 2003, v. 17 n. 5, p. 454-458 How to Cite? |
Abstract | Capsaicin (8-methyl-n-vanillyl-6-nonenamide), a pungent component found in red pepper can induce body heat and possibly enhance blood flow as well as increase energy expenditure, and prevent oxidative stress. Male Wistar rats were divided into vehicle, 1 mg/kg body weight capsaicin and 3 mg/kg body weight capsaicin groups. Samples were taken from the animals on day 1 of i.p. treatment with capsaicin and on 3 consecutive days of i.p. treatment with capsaicin. Our investigation demonstrated that blood flow measurements in rats was negatively correlated with LDL after treatment with capsaicin. Although capsaicin did not show a noticeable effect on the serum total cholesterol level, LDL decreased while HDL and triglyceride increased in rats treated with 3 mg/kg capsaicin for 3 days. The antioxidant effect of capsaicin was not shown when the rats were treated with 1 mg/kg body weight capsaicin. However, rats treated with 3 mg/kg body weight capsaicin for 3 days showed a reduction of oxidative stress measured as malondialdehyde in the liver, lung, kidney and muscle. Liver glycogen was found to decrease after 3 days treatment with 3 mg/kg body weight capsaicin. From this study, it is hypothesized that capsaicin can be a potent antioxidant and aid in lowering LDL even when consumed for a short period. Copyright © 2003 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/178800 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.277 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CYJ | en_US |
dc.contributor.author | Kim, M | en_US |
dc.contributor.author | Yoon, SW | en_US |
dc.contributor.author | Lee, CH | en_US |
dc.date.accessioned | 2012-12-19T09:49:49Z | - |
dc.date.available | 2012-12-19T09:49:49Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Phytotherapy Research, 2003, v. 17 n. 5, p. 454-458 | en_US |
dc.identifier.issn | 0951-418X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178800 | - |
dc.description.abstract | Capsaicin (8-methyl-n-vanillyl-6-nonenamide), a pungent component found in red pepper can induce body heat and possibly enhance blood flow as well as increase energy expenditure, and prevent oxidative stress. Male Wistar rats were divided into vehicle, 1 mg/kg body weight capsaicin and 3 mg/kg body weight capsaicin groups. Samples were taken from the animals on day 1 of i.p. treatment with capsaicin and on 3 consecutive days of i.p. treatment with capsaicin. Our investigation demonstrated that blood flow measurements in rats was negatively correlated with LDL after treatment with capsaicin. Although capsaicin did not show a noticeable effect on the serum total cholesterol level, LDL decreased while HDL and triglyceride increased in rats treated with 3 mg/kg capsaicin for 3 days. The antioxidant effect of capsaicin was not shown when the rats were treated with 1 mg/kg body weight capsaicin. However, rats treated with 3 mg/kg body weight capsaicin for 3 days showed a reduction of oxidative stress measured as malondialdehyde in the liver, lung, kidney and muscle. Liver glycogen was found to decrease after 3 days treatment with 3 mg/kg body weight capsaicin. From this study, it is hypothesized that capsaicin can be a potent antioxidant and aid in lowering LDL even when consumed for a short period. Copyright © 2003 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | en_US |
dc.relation.ispartof | Phytotherapy Research | en_US |
dc.subject | Antioxidant | - |
dc.subject | Capsaicin | - |
dc.subject | LDL | - |
dc.subject | MC-FAN | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antioxidants - Pharmacology | en_US |
dc.subject.mesh | Blood Glucose - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Capsaicin - Pharmacology | en_US |
dc.subject.mesh | Capsicum | en_US |
dc.subject.mesh | Cholesterol, Hdl - Blood - Drug Effects | en_US |
dc.subject.mesh | Cholesterol, Ldl - Blood - Drug Effects | en_US |
dc.subject.mesh | Liver Glycogen - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Malondialdehyde - Blood | en_US |
dc.subject.mesh | Oxidative Stress - Drug Effects | en_US |
dc.subject.mesh | Plant Extracts - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Wistar | en_US |
dc.subject.mesh | Regional Blood Flow - Drug Effects | en_US |
dc.subject.mesh | Triglycerides - Blood | en_US |
dc.title | Short-term control of capsaicin on blood and oxidative stress of rats in vivo | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, CYJ: jettylee@hku.hk | en_US |
dc.identifier.authority | Lee, CYJ=rp01511 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/ptr.1172 | en_US |
dc.identifier.pmid | 12748978 | - |
dc.identifier.scopus | eid_2-s2.0-0038187756 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0038187756&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 454 | en_US |
dc.identifier.epage | 458 | en_US |
dc.identifier.isi | WOS:000182932100003 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lee, CYJ=13104265200 | en_US |
dc.identifier.scopusauthorid | Kim, M=36063270400 | en_US |
dc.identifier.scopusauthorid | Yoon, SW=13407062300 | en_US |
dc.identifier.scopusauthorid | Lee, CH=7410151030 | en_US |
dc.identifier.issnl | 0951-418X | - |