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- Publisher Website: 10.1007/s12031-008-9083-5
- Scopus: eid_2-s2.0-58149089287
- PMID: 18566919
- WOS: WOS:000261180200016
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Conference Paper: A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression
Title | A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression |
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Authors | |
Keywords | Gene expression Secretin Variable number of tandem repeats |
Issue Date | 2008 |
Citation | The 8th International Symposium on VIP, PACAP and Related Peptides. Symposium dedicated to the memory of Akira Arimura, Manchester, VT, 3-8 September 2007. In Journal Of Molecular Neuroscience, 2008, v. 36 n. 1-3, p. 125-131 How to Cite? |
Abstract | Secretin is a peptide hormone playing multiple functions in the brain-gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals. © 2008 Humana Press. |
Persistent Identifier | http://hdl.handle.net/10722/179109 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.747 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, LTO | en_US |
dc.contributor.author | Lam, IPY | en_US |
dc.contributor.author | Chow, BKC | en_US |
dc.date.accessioned | 2012-12-19T09:52:03Z | - |
dc.date.available | 2012-12-19T09:52:03Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | The 8th International Symposium on VIP, PACAP and Related Peptides. Symposium dedicated to the memory of Akira Arimura, Manchester, VT, 3-8 September 2007. In Journal Of Molecular Neuroscience, 2008, v. 36 n. 1-3, p. 125-131 | en_US |
dc.identifier.issn | 0895-8696 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179109 | - |
dc.description.abstract | Secretin is a peptide hormone playing multiple functions in the brain-gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals. © 2008 Humana Press. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Molecular Neuroscience | en_US |
dc.subject | Gene expression | - |
dc.subject | Secretin | - |
dc.subject | Variable number of tandem repeats | - |
dc.subject.mesh | 5' Flanking Region - Genetics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Down-Regulation | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Minisatellite Repeats | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Promoter Regions, Genetic | en_US |
dc.subject.mesh | Secretin - Genetics - Metabolism | en_US |
dc.subject.mesh | Sequence Alignment | en_US |
dc.title | A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Lee, LTO: ltolee2@hkucc.hku.hk | en_US |
dc.identifier.email | Chow, BKC: bkcc@hku.hk | en_US |
dc.identifier.authority | Lee, LTO=rp00727 | en_US |
dc.identifier.authority | Chow, BKC=rp00681 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s12031-008-9083-5 | en_US |
dc.identifier.pmid | 18566919 | - |
dc.identifier.scopus | eid_2-s2.0-58149089287 | en_US |
dc.identifier.hkuros | 156841 | - |
dc.identifier.hkuros | 181127 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-58149089287&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 1-3 | en_US |
dc.identifier.spage | 125 | en_US |
dc.identifier.epage | 131 | en_US |
dc.identifier.isi | WOS:000261180200016 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, LTO=8367269000 | en_US |
dc.identifier.scopusauthorid | Lam, IPY=14050702700 | en_US |
dc.identifier.scopusauthorid | Chow, BKC=7102826193 | en_US |
dc.identifier.issnl | 0895-8696 | - |