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Article: Oxidative damage in dengue fever

TitleOxidative damage in dengue fever
Authors
KeywordsDengue
F2-isoprostanes
Free radicals
HETEs
Oxidative stress
Oxidized lipid products
Oxysterols
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
Citation
Free Radical Biology And Medicine, 2009, v. 47 n. 4, p. 375-380 How to Cite?
AbstractOxidative stress may be important in the pathogenesis of dengue infection. Using accurate markers of oxidative damage, we assessed the extent of oxidative damage in dengue patients. The levels of hydroxyeicosatetraenoic acid products (HETEs), F 2-isoprostanes (F 2-IsoPs), and cholesterol oxidation products (COPs) were measured in 28 adult dengue patients and 28 age-matched study controls during the febrile, defervescent, and convalescent stages of infection. We compared the absolute and the percentage change in these markers in relation to key clinical parameters and inflammatory markers. The levels of total HETEs and total HETEs/arachidonate, total F 2-IsoPs/arachidonate, and COPs/cholesterol were higher during the febrile compared to the convalescent level. Total HETEs correlated positively with admission systolic blood pressure (r = 0.52, p < 0.05), whereas an inverse relationship was found between 7β-hydroxycholesterol and systolic and diastolic blood pressure (r = -0.61 and -0.59, respectively, p < 0.01). The urinary F 2-IsoP level was higher in urine during the febrile stage compared to the convalescent level. Despite lower total cholesterol levels during the febrile stage compared to convalescent levels, a higher percentage of cholesterol was found as COPs (7β-, 24-, and 27-hydroxycholesterol). The levels of platelet-activating factor-acetylhydrolase activity, vascular cellular adhesion molecule-1, tumor necrosis factor-α, and high-sensitivity C-reactive protein were higher during the febrile stage compared to their convalescent levels (p < 0.01). Markers of oxidative damage are altered during the various stages of dengue infection. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179141
ISSN
2023 Impact Factor: 7.1
2023 SCImago Journal Rankings: 1.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeet, RCSen_US
dc.contributor.authorLee, CYJen_US
dc.contributor.authorLim, ECHen_US
dc.contributor.authorQuek, AMLen_US
dc.contributor.authorYeo, LLLen_US
dc.contributor.authorHuang, SHen_US
dc.contributor.authorHalliwell, Ben_US
dc.date.accessioned2012-12-19T09:52:18Z-
dc.date.available2012-12-19T09:52:18Z-
dc.date.issued2009en_US
dc.identifier.citationFree Radical Biology And Medicine, 2009, v. 47 n. 4, p. 375-380en_US
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/10722/179141-
dc.description.abstractOxidative stress may be important in the pathogenesis of dengue infection. Using accurate markers of oxidative damage, we assessed the extent of oxidative damage in dengue patients. The levels of hydroxyeicosatetraenoic acid products (HETEs), F 2-isoprostanes (F 2-IsoPs), and cholesterol oxidation products (COPs) were measured in 28 adult dengue patients and 28 age-matched study controls during the febrile, defervescent, and convalescent stages of infection. We compared the absolute and the percentage change in these markers in relation to key clinical parameters and inflammatory markers. The levels of total HETEs and total HETEs/arachidonate, total F 2-IsoPs/arachidonate, and COPs/cholesterol were higher during the febrile compared to the convalescent level. Total HETEs correlated positively with admission systolic blood pressure (r = 0.52, p < 0.05), whereas an inverse relationship was found between 7β-hydroxycholesterol and systolic and diastolic blood pressure (r = -0.61 and -0.59, respectively, p < 0.01). The urinary F 2-IsoP level was higher in urine during the febrile stage compared to the convalescent level. Despite lower total cholesterol levels during the febrile stage compared to convalescent levels, a higher percentage of cholesterol was found as COPs (7β-, 24-, and 27-hydroxycholesterol). The levels of platelet-activating factor-acetylhydrolase activity, vascular cellular adhesion molecule-1, tumor necrosis factor-α, and high-sensitivity C-reactive protein were higher during the febrile stage compared to their convalescent levels (p < 0.01). Markers of oxidative damage are altered during the various stages of dengue infection. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomeden_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.subjectDengue-
dc.subjectF2-isoprostanes-
dc.subjectFree radicals-
dc.subjectHETEs-
dc.subjectOxidative stress-
dc.subjectOxidized lipid products-
dc.subjectOxysterols-
dc.subject.mesh1-Alkyl-2-Acetylglycerophosphocholine Esterase - Genetics - Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiological Markers - Blood - Urineen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshC-Reactive Protein - Genetics - Metabolismen_US
dc.subject.meshCholesterol - Analogs & Derivatives - Blood - Urineen_US
dc.subject.meshDengue - Blood - Genetics - Physiopathologyen_US
dc.subject.meshDengue Virus - Pathogenicity - Physiologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshF2-Isoprostanes - Blood - Urineen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxyeicosatetraenoic Acids - Blood - Urineen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Genetics - Metabolismen_US
dc.subject.meshVirulenceen_US
dc.titleOxidative damage in dengue feveren_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.freeradbiomed.2009.04.035en_US
dc.identifier.pmid19427377-
dc.identifier.scopuseid_2-s2.0-67649867918en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649867918&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue4en_US
dc.identifier.spage375en_US
dc.identifier.epage380en_US
dc.identifier.isiWOS:000268386100005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSeet, RCS=10045357300en_US
dc.identifier.scopusauthoridLee, CYJ=13104265200en_US
dc.identifier.scopusauthoridLim, ECH=8945547100en_US
dc.identifier.scopusauthoridQuek, AML=13605538000en_US
dc.identifier.scopusauthoridYeo, LLL=16403624500en_US
dc.identifier.scopusauthoridHuang, SH=8367750600en_US
dc.identifier.scopusauthoridHalliwell, B=7101878919en_US
dc.identifier.citeulike4760117-
dc.identifier.issnl0891-5849-

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