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- Publisher Website: 10.1016/S0024-3205(03)00649-0
- Scopus: eid_2-s2.0-0041828392
- PMID: 12954453
- WOS: WOS:000185224200005
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Article: The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure
Title | The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure |
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Authors | |
Keywords | Aluminum Alzheimer's disease Dipsacus asper Passive avoidance task Rat Vitamin E β-amyloid protein |
Issue Date | 2003 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 2003, v. 73 n. 19, p. 2443-2454 How to Cite? |
Abstract | Excess aluminum (Al) exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential link between chronic Al exposure and Alzheimer's disease. In the present study, we sought to evaluate the protective effects of the herbal medicine Dipsacus asper extract against the cognitive impairment and overexpression of hippocampal β-amyloid protein (Aβ) induced by chronic Al exposure in rats. Vitamin E (VE) was used as a positive control. Following exposure to 0.3% aluminum chloride (AlCl 3) solution for 90 days in their drinking water, animals displayed a striking decrease (>80%) in step-through latency in the passive avoidance task and a significant increase (123%) in the number of Aβ immunoreactive cells in the hippocampus compared to controls. Al-exposed animals were then randomly assigned to receive vehicle, Dipsacus asper extract (4 g/kg), or VE (40 mg/kg) treatment up to 5 months. Both Dipsacus asper extract and VE significantly ameliorated animal's performance impairment in the passive avoidance task and suppressed the overexpression of hippocampal Aβ immunoreactivity. The effects of Dipsacus asper extract, but not VE, increased with time of treatment. The present results suggest that Dipsacus asper extract may possess therapeutic effects against Alzheimer's disease. © 2003 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/179417 |
ISSN | 2021 Impact Factor: 6.780 2020 SCImago Journal Rankings: 1.131 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhang, ZJ | en_US |
dc.contributor.author | Qian, YH | en_US |
dc.contributor.author | Hu, HT | en_US |
dc.contributor.author | Yang, J | en_US |
dc.contributor.author | Yang, GD | en_US |
dc.date.accessioned | 2012-12-19T09:56:18Z | - |
dc.date.available | 2012-12-19T09:56:18Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Life Sciences, 2003, v. 73 n. 19, p. 2443-2454 | en_US |
dc.identifier.issn | 0024-3205 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179417 | - |
dc.description.abstract | Excess aluminum (Al) exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential link between chronic Al exposure and Alzheimer's disease. In the present study, we sought to evaluate the protective effects of the herbal medicine Dipsacus asper extract against the cognitive impairment and overexpression of hippocampal β-amyloid protein (Aβ) induced by chronic Al exposure in rats. Vitamin E (VE) was used as a positive control. Following exposure to 0.3% aluminum chloride (AlCl 3) solution for 90 days in their drinking water, animals displayed a striking decrease (>80%) in step-through latency in the passive avoidance task and a significant increase (123%) in the number of Aβ immunoreactive cells in the hippocampus compared to controls. Al-exposed animals were then randomly assigned to receive vehicle, Dipsacus asper extract (4 g/kg), or VE (40 mg/kg) treatment up to 5 months. Both Dipsacus asper extract and VE significantly ameliorated animal's performance impairment in the passive avoidance task and suppressed the overexpression of hippocampal Aβ immunoreactivity. The effects of Dipsacus asper extract, but not VE, increased with time of treatment. The present results suggest that Dipsacus asper extract may possess therapeutic effects against Alzheimer's disease. © 2003 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | en_US |
dc.relation.ispartof | Life Sciences | en_US |
dc.subject | Aluminum | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Dipsacus asper | - |
dc.subject | Passive avoidance task | - |
dc.subject | Rat | - |
dc.subject | Vitamin E | - |
dc.subject | β-amyloid protein | - |
dc.subject.mesh | Administration, Oral | en_US |
dc.subject.mesh | Aluminum Compounds - Toxicity | en_US |
dc.subject.mesh | Amyloid Beta-Peptides - Biosynthesis | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Avoidance Learning - Drug Effects | en_US |
dc.subject.mesh | Chlorides - Toxicity | en_US |
dc.subject.mesh | Drugs, Chinese Herbal - Pharmacology | en_US |
dc.subject.mesh | Hippocampus - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Vitamin E - Pharmacology | en_US |
dc.title | The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhang, ZJ: zhangzj@hkucc.hku.hk | en_US |
dc.identifier.authority | Zhang, ZJ=rp01297 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0024-3205(03)00649-0 | en_US |
dc.identifier.pmid | 12954453 | - |
dc.identifier.scopus | eid_2-s2.0-0041828392 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0041828392&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 73 | en_US |
dc.identifier.issue | 19 | en_US |
dc.identifier.spage | 2443 | en_US |
dc.identifier.epage | 2454 | en_US |
dc.identifier.isi | WOS:000185224200005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhang, ZJ=8061473900 | en_US |
dc.identifier.scopusauthorid | Qian, YH=8061474000 | en_US |
dc.identifier.scopusauthorid | Hu, HT=35305074400 | en_US |
dc.identifier.scopusauthorid | Yang, J=8928087300 | en_US |
dc.identifier.scopusauthorid | Yang, GD=8627524400 | en_US |
dc.identifier.issnl | 0024-3205 | - |