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- Publisher Website: 10.1002/ptr.3269
- Scopus: eid_2-s2.0-79952232564
- PMID: 20740476
- WOS: WOS:000288133000019
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Article: Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells
Title | Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells |
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Authors | |
Keywords | Beta-amyloid Dibenzocyclooctadiene lignans Homocysteine Schisandra chinensis (Turcz.) Baill. Schisandrin B Schisandrin C |
Issue Date | 2011 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 |
Citation | Phytotherapy Research, 2011, v. 25 n. 3, p. 435-443 How to Cite? |
Abstract | Aggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) againstAβ 25-35 and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5 μM Aβ 25-35 caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro-apoptotic protein Bax and caspase-3 activation. All these effects induced byAβ 25-35 were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine-induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against Aβ toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase-3. Further structure-activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright © 2010 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/179457 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.277 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, JX | en_US |
dc.contributor.author | Lin, X | en_US |
dc.contributor.author | Wong, RNS | en_US |
dc.contributor.author | Sze, SCW | en_US |
dc.contributor.author | Tong, Y | en_US |
dc.contributor.author | Shaw, PC | en_US |
dc.contributor.author | Zhang, YB | en_US |
dc.date.accessioned | 2012-12-19T09:56:45Z | - |
dc.date.available | 2012-12-19T09:56:45Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Phytotherapy Research, 2011, v. 25 n. 3, p. 435-443 | en_US |
dc.identifier.issn | 0951-418X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179457 | - |
dc.description.abstract | Aggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) againstAβ 25-35 and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5 μM Aβ 25-35 caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro-apoptotic protein Bax and caspase-3 activation. All these effects induced byAβ 25-35 were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine-induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against Aβ toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase-3. Further structure-activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright © 2010 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | en_US |
dc.relation.ispartof | Phytotherapy Research | en_US |
dc.subject | Beta-amyloid | - |
dc.subject | Dibenzocyclooctadiene lignans | - |
dc.subject | Homocysteine | - |
dc.subject | Schisandra chinensis (Turcz.) Baill. | - |
dc.subject | Schisandrin B | - |
dc.subject | Schisandrin C | - |
dc.subject.mesh | Amyloid Beta-Peptides - Toxicity | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apoptosis - Drug Effects | en_US |
dc.subject.mesh | Caspase 3 - Metabolism | en_US |
dc.subject.mesh | Cyclooctanes - Pharmacology | en_US |
dc.subject.mesh | Dioxoles | en_US |
dc.subject.mesh | Homocysteine - Toxicity | en_US |
dc.subject.mesh | Lignans - Pharmacology | en_US |
dc.subject.mesh | Neuroprotective Agents - Pharmacology | en_US |
dc.subject.mesh | Pc12 Cells | en_US |
dc.subject.mesh | Peptide Fragments - Toxicity | en_US |
dc.subject.mesh | Polycyclic Compounds | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Reactive Oxygen Species - Metabolism | en_US |
dc.subject.mesh | Schisandra - Chemistry | en_US |
dc.subject.mesh | Bcl-2-Associated X Protein - Metabolism | en_US |
dc.title | Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sze, SCW: stephens@hku.hk | en_US |
dc.identifier.email | Tong, Y: tongyao@hku.hk | en_US |
dc.identifier.email | Zhang, YB: ybzhang@hku.hk | en_US |
dc.identifier.authority | Sze, SCW=rp00514 | en_US |
dc.identifier.authority | Tong, Y=rp00509 | en_US |
dc.identifier.authority | Zhang, YB=rp01410 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/ptr.3269 | en_US |
dc.identifier.pmid | 20740476 | - |
dc.identifier.scopus | eid_2-s2.0-79952232564 | en_US |
dc.identifier.hkuros | 172907 | - |
dc.identifier.hkuros | 197192 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79952232564&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 435 | en_US |
dc.identifier.epage | 443 | en_US |
dc.identifier.isi | WOS:000288133000019 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Song, JX=24339343800 | en_US |
dc.identifier.scopusauthorid | Lin, X=36101204400 | en_US |
dc.identifier.scopusauthorid | Wong, RNS=7402126957 | en_US |
dc.identifier.scopusauthorid | Sze, SCW=23482617000 | en_US |
dc.identifier.scopusauthorid | Tong, Y=9045384000 | en_US |
dc.identifier.scopusauthorid | Shaw, PC=35599523600 | en_US |
dc.identifier.scopusauthorid | Zhang, YB=23483121900 | en_US |
dc.identifier.issnl | 0951-418X | - |