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- Scopus: eid_2-s2.0-0020083436
- PMID: 7061990
- WOS: WOS:A1982NF49000006
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Article: Monoclonal antibodies against the flavivirus West Nile
Title | Monoclonal antibodies against the flavivirus West Nile |
---|---|
Authors | |
Issue Date | 1982 |
Publisher | Society for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org |
Citation | Journal Of General Virology, 1982, v. 58 n. 2, p. 283-289 How to Cite? |
Abstract | Monoclonal antibodies having three different specificities have been prepared against the Egypt 101 strain of West Nile virus (WNV). All were reactive against the envelope glycoprotein in radioimmune precipitation tests, and all enhanced WNV replication in the mouse macrophage line P388D1. One antibody, which is of IgG2a subclass, had strong neutralizing activity against the homologous virus, although it failed to neutralize a different WNV strain. The other two antibodies, both of IgG1 subclass, had little neutralizing activity, but one had strong reactivity with the haemagglutinin of the inducing virus and other flavivirus haemagglutinins. |
Persistent Identifier | http://hdl.handle.net/10722/179730 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 0.990 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Porterfield, JS | en_US |
dc.contributor.author | Roehrig, JT | en_US |
dc.date.accessioned | 2012-12-19T10:04:07Z | - |
dc.date.available | 2012-12-19T10:04:07Z | - |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | Journal Of General Virology, 1982, v. 58 n. 2, p. 283-289 | en_US |
dc.identifier.issn | 0022-1317 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179730 | - |
dc.description.abstract | Monoclonal antibodies having three different specificities have been prepared against the Egypt 101 strain of West Nile virus (WNV). All were reactive against the envelope glycoprotein in radioimmune precipitation tests, and all enhanced WNV replication in the mouse macrophage line P388D1. One antibody, which is of IgG2a subclass, had strong neutralizing activity against the homologous virus, although it failed to neutralize a different WNV strain. The other two antibodies, both of IgG1 subclass, had little neutralizing activity, but one had strong reactivity with the haemagglutinin of the inducing virus and other flavivirus haemagglutinins. | en_US |
dc.language | eng | en_US |
dc.publisher | Society for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org | en_US |
dc.relation.ispartof | Journal of General Virology | en_US |
dc.subject.mesh | Antibodies, Monoclonal - Immunology | en_US |
dc.subject.mesh | Antibodies, Viral - Immunology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Hemagglutination Inhibition Tests | en_US |
dc.subject.mesh | Macrophages | en_US |
dc.subject.mesh | Neutralization Tests | en_US |
dc.subject.mesh | Precipitin Tests | en_US |
dc.subject.mesh | Viral Envelope Proteins | en_US |
dc.subject.mesh | Viral Plaque Assay | en_US |
dc.subject.mesh | Viral Proteins - Immunology | en_US |
dc.subject.mesh | West Nile Virus - Growth & Development - Immunology | en_US |
dc.title | Monoclonal antibodies against the flavivirus West Nile | en_US |
dc.type | Article | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 7061990 | - |
dc.identifier.scopus | eid_2-s2.0-0020083436 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 283 | en_US |
dc.identifier.epage | 289 | en_US |
dc.identifier.isi | WOS:A1982NF49000006 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_US |
dc.identifier.scopusauthorid | Porterfield, JS=7005608715 | en_US |
dc.identifier.scopusauthorid | Roehrig, JT=7005611442 | en_US |
dc.identifier.issnl | 0022-1317 | - |