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Article: Mx1 gene protects mice against the highly lethal human H5N1 influenza virus

TitleMx1 gene protects mice against the highly lethal human H5N1 influenza virus
Authors
Salomon, RStaeheli, PKochs, GYen, HLFranks, JRehg, JEWebster, RGHoffmann, E
KeywordsH5N1
Influenza
Mx1
Polymerase
Protection
Issue Date2007
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cc
Citation
Cell Cycle, 2007, v. 6 n. 19, p. 2417-2421 How to Cite?
DOI: http://dx.doi.org/10.4161/cc.6.19.4779
AbstractWe investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1-/- mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer lesions, and less pulmonary inflammation. Our data support the hypothesis that Mx1 expression protects mice against the high pathogenicity of H5N1 virus through inhibition of viral polymerase activity ultimately resulting in reduced viral growth and spread. Drugs that mimic this mechanism may be protective in humans. ©2007 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/179804
ISSN
1538-4101
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 0.947
ISI Accession Number ID
WOS:000251085700018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSalomon, Ren_US
dc.contributor.authorStaeheli, Pen_US
dc.contributor.authorKochs, Gen_US
dc.contributor.authorYen, HLen_US
dc.contributor.authorFranks, Jen_US
dc.contributor.authorRehg, JEen_US
dc.contributor.authorWebster, RGen_US
dc.contributor.authorHoffmann, Een_US
dc.date.accessioned2012-12-19T10:04:57Z-
dc.date.available2012-12-19T10:04:57Z-
dc.date.issued2007en_US
dc.identifier.citationCell Cycle, 2007, v. 6 n. 19, p. 2417-2421en_US
dc.identifier.issn1538-4101en_US
dc.identifier.urihttp://hdl.handle.net/10722/179804-
dc.description.abstractWe investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1-/- mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer lesions, and less pulmonary inflammation. Our data support the hypothesis that Mx1 expression protects mice against the high pathogenicity of H5N1 virus through inhibition of viral polymerase activity ultimately resulting in reduced viral growth and spread. Drugs that mimic this mechanism may be protective in humans. ©2007 Landes Bioscience.en_US
dc.languageengen_US
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/ccen_US
dc.relation.ispartofCell Cycleen_US
dc.subjectH5N1-
dc.subjectInfluenza-
dc.subjectMx1-
dc.subjectPolymerase-
dc.subjectProtection-
dc.subject.meshAnimalsen_US
dc.subject.meshChickensen_US
dc.subject.meshGtp-Binding Proteins - Genetics - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Metabolismen_US
dc.subject.meshInfluenza, Human - Immunology - Virologyen_US
dc.subject.meshLiver - Cytology - Metabolismen_US
dc.subject.meshLung - Cytology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshOrthomyxoviridae Infections - Immunology - Virologyen_US
dc.subject.meshViral Proteins - Metabolismen_US
dc.titleMx1 gene protects mice against the highly lethal human H5N1 influenza virusen_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4161/cc.6.19.4779-
dc.identifier.pmid17700072-
dc.identifier.scopuseid_2-s2.0-35848938278en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35848938278&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue19en_US
dc.identifier.spage2417en_US
dc.identifier.epage2421en_US
dc.identifier.isiWOS:000251085700018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSalomon, R=12786463900en_US
dc.identifier.scopusauthoridStaeheli, P=7004400156en_US
dc.identifier.scopusauthoridKochs, G=7003794464en_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridFranks, J=12786180500en_US
dc.identifier.scopusauthoridRehg, JE=7004835777en_US
dc.identifier.scopusauthoridWebster, RG=36048363100en_US
dc.identifier.scopusauthoridHoffmann, E=7201369718en_US
dc.identifier.issnl1551-4005-

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