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- Publisher Website: 10.1002/pd.1970060202
- Scopus: eid_2-s2.0-0022591994
- PMID: 2422642
- WOS: WOS:A1986A786600001
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Article: Justification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defects
Title | Justification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defects |
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Authors | |
Keywords | Low risk population Neural tube defects Screening Serum alphafetoprotein |
Issue Date | 1986 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 1986, v. 6 n. 2, p. 83-87 How to Cite? |
Abstract | A prospective study of maternal serum alphafetoprotein (α-FP) screening of 9838 women in an area with low prevalence of neural tube defects and predominance of anencephalics revealed that an intervention point of single serum α-FP level above 2·8 times the median was appropriate for this population. Ninety per cent of anencephalics and all fetuses with anterior abdominal wall defects were detected. There was no spina bifida among the population screened. Two per cent of the population screened had serum α-FP level above this cut-off level. Thirty-two per cent of twin pregnancies, 7 per cent of small-for-gestational age infants and 9 per cent of pregnancies which ended in either abortion or perinatal death in the population screened also had one serum α-FP level above this intervention point. The false positive rate was 66 per cent. This false positive rate was only reduced to 63 per cent if insted of one, two serum α-FP level above this intervention point was considered abnormal. Using this strategy there was no significant reduction in the detection rate of fetal anomalies and other pregnancy complications. Because of the predominance of anencephalics in this population the diagnosis of fetas anomaly in women with abnormal serum α-FP level was made by ultrasound examination alone. The reason amniocentesis was not performed in these patients was to avoid unnecessary loss of normal pregnancies which may result from this procedure. |
Persistent Identifier | http://hdl.handle.net/10722/180615 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ghosh, A | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.contributor.author | Tai, D | en_US |
dc.contributor.author | Nie, G | en_US |
dc.contributor.author | Ma, HK | en_US |
dc.date.accessioned | 2013-01-28T01:40:40Z | - |
dc.date.available | 2013-01-28T01:40:40Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 1986, v. 6 n. 2, p. 83-87 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180615 | - |
dc.description.abstract | A prospective study of maternal serum alphafetoprotein (α-FP) screening of 9838 women in an area with low prevalence of neural tube defects and predominance of anencephalics revealed that an intervention point of single serum α-FP level above 2·8 times the median was appropriate for this population. Ninety per cent of anencephalics and all fetuses with anterior abdominal wall defects were detected. There was no spina bifida among the population screened. Two per cent of the population screened had serum α-FP level above this cut-off level. Thirty-two per cent of twin pregnancies, 7 per cent of small-for-gestational age infants and 9 per cent of pregnancies which ended in either abortion or perinatal death in the population screened also had one serum α-FP level above this intervention point. The false positive rate was 66 per cent. This false positive rate was only reduced to 63 per cent if insted of one, two serum α-FP level above this intervention point was considered abnormal. Using this strategy there was no significant reduction in the detection rate of fetal anomalies and other pregnancy complications. Because of the predominance of anencephalics in this population the diagnosis of fetas anomaly in women with abnormal serum α-FP level was made by ultrasound examination alone. The reason amniocentesis was not performed in these patients was to avoid unnecessary loss of normal pregnancies which may result from this procedure. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | Low risk population | - |
dc.subject | Neural tube defects | - |
dc.subject | Screening | - |
dc.subject | Serum alphafetoprotein | - |
dc.subject.mesh | Anencephaly - Diagnosis | en_US |
dc.subject.mesh | False Positive Reactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Neural Tube Defects - Diagnosis | en_US |
dc.subject.mesh | Pilot Projects | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Trimester, Second | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Alpha-Fetoproteins - Analysis | en_US |
dc.title | Justification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defects | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/pd.1970060202 | - |
dc.identifier.pmid | 2422642 | - |
dc.identifier.scopus | eid_2-s2.0-0022591994 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 83 | en_US |
dc.identifier.epage | 87 | en_US |
dc.identifier.isi | WOS:A1986A786600001 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Ghosh, A=7403963873 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.scopusauthorid | Tai, D=35863000800 | en_US |
dc.identifier.scopusauthorid | Nie, G=55528515600 | en_US |
dc.identifier.scopusauthorid | Ma, HK=36986403800 | en_US |
dc.identifier.issnl | 0197-3851 | - |