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- Publisher Website: 10.1016/S0002-9378(99)70165-1
- Scopus: eid_2-s2.0-0033024166
- PMID: 9914594
- WOS: WOS:000078224200027
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Article: Prenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestation
Title | Prenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestation |
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Authors | |
Keywords | Fetal heart Prenatal diagnosis Ultrasonography α-thalassemia |
Issue Date | 1999 |
Publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajog |
Citation | American Journal Of Obstetrics And Gynecology, 1999, v. 180 n. 1 I, p. 148-150 How to Cite? |
Abstract | We determined the feasibility of prenatal prediction of type 1 homozygous α-thalassemia at 12 to 13 weeks of gestation by either abdominal or vaginal (or both) ultrasonographic examination to measure the fetal cardiothoracic ratio in 135 at-risk pregnancies. Forty-three fetuses were affected by homozygous type 1 α-thalassemia. The mean cardiothoracic ratio was significantly larger than that of the unaffected fetuses (0.54 vs 0.45, P < .0005), with no overlap between the 2 groups. A cardiothoracic ratio cutoff point of ≥0.5 was 100% sensitive and specific for disease. |
Persistent Identifier | http://hdl.handle.net/10722/180649 |
ISSN | 2023 Impact Factor: 8.7 2023 SCImago Journal Rankings: 3.024 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, YH | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.contributor.author | Lee, CP | en_US |
dc.contributor.author | Tse, HY | en_US |
dc.date.accessioned | 2013-01-28T01:40:52Z | - |
dc.date.available | 2013-01-28T01:40:52Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | American Journal Of Obstetrics And Gynecology, 1999, v. 180 n. 1 I, p. 148-150 | en_US |
dc.identifier.issn | 0002-9378 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180649 | - |
dc.description.abstract | We determined the feasibility of prenatal prediction of type 1 homozygous α-thalassemia at 12 to 13 weeks of gestation by either abdominal or vaginal (or both) ultrasonographic examination to measure the fetal cardiothoracic ratio in 135 at-risk pregnancies. Forty-three fetuses were affected by homozygous type 1 α-thalassemia. The mean cardiothoracic ratio was significantly larger than that of the unaffected fetuses (0.54 vs 0.45, P < .0005), with no overlap between the 2 groups. A cardiothoracic ratio cutoff point of ≥0.5 was 100% sensitive and specific for disease. | en_US |
dc.language | eng | en_US |
dc.publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajog | en_US |
dc.relation.ispartof | American Journal of Obstetrics and Gynecology | en_US |
dc.subject | Fetal heart | - |
dc.subject | Prenatal diagnosis | - |
dc.subject | Ultrasonography | - |
dc.subject | α-thalassemia | - |
dc.subject.mesh | Feasibility Studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Heart - Ultrasonography | en_US |
dc.subject.mesh | Forecasting | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Thorax - Embryology - Ultrasonography | en_US |
dc.subject.mesh | Ultrasonography, Prenatal | en_US |
dc.subject.mesh | Alpha-Thalassemia - Genetics - Ultrasonography | en_US |
dc.title | Prenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0002-9378(99)70165-1 | en_US |
dc.identifier.pmid | 9914594 | - |
dc.identifier.scopus | eid_2-s2.0-0033024166 | en_US |
dc.identifier.volume | 180 | en_US |
dc.identifier.issue | 1 I | en_US |
dc.identifier.spage | 148 | en_US |
dc.identifier.epage | 150 | en_US |
dc.identifier.isi | WOS:000078224200027 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=35362943900 | en_US |
dc.identifier.scopusauthorid | Lee, CP=7410149538 | en_US |
dc.identifier.scopusauthorid | Tse, HY=36772585300 | en_US |
dc.identifier.issnl | 0002-9378 | - |