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- Publisher Website: 10.1002/pd.1096
- Scopus: eid_2-s2.0-14744267781
- PMID: 15712347
- WOS: WOS:000227342300004
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Article: Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood
Title | Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood |
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Authors | |
Keywords | Globin Hb Bart's Noninvasive |
Issue Date | 2005 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 2005, v. 25 n. 2, p. 123-128 How to Cite? |
Abstract | Objective: To investigate a simple non-invasive technique for early detection of Hemoglobin (Hb) Bart's disease. Method: Maternal blood smears from 8 known Hb Bart's pregnancies and 40 at-risk pregnancies were investigated. Maternal peripheral blood smears were stained with fluorescence-labeled monoclonal antibodies against α- and embryonic ζ-globin chains. Results: Fetal nonnucleated red blood cells, stained with anti-ζ but not with anti-α globin antibodies were found in 15 out of 16 affected pregnancies but were not detected in 23 out of 24 unaffected pregnancies. Conclusion: Results showed that non-invasive immunofluorescence staining of maternal blood is a feasible approach for screening Hb Bart's disease before ultrasound manifestation in affected pregnancies. Copyright © 2005 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/180671 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, ET | en_US |
dc.contributor.author | Kwok, YK | en_US |
dc.contributor.author | Luo, HY | en_US |
dc.contributor.author | Leung, KY | en_US |
dc.contributor.author | Lee, CP | en_US |
dc.contributor.author | Lam, YH | en_US |
dc.contributor.author | Chui, DHK | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.date.accessioned | 2013-01-28T01:41:00Z | - |
dc.date.available | 2013-01-28T01:41:00Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 2005, v. 25 n. 2, p. 123-128 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180671 | - |
dc.description.abstract | Objective: To investigate a simple non-invasive technique for early detection of Hemoglobin (Hb) Bart's disease. Method: Maternal blood smears from 8 known Hb Bart's pregnancies and 40 at-risk pregnancies were investigated. Maternal peripheral blood smears were stained with fluorescence-labeled monoclonal antibodies against α- and embryonic ζ-globin chains. Results: Fetal nonnucleated red blood cells, stained with anti-ζ but not with anti-α globin antibodies were found in 15 out of 16 affected pregnancies but were not detected in 23 out of 24 unaffected pregnancies. Conclusion: Results showed that non-invasive immunofluorescence staining of maternal blood is a feasible approach for screening Hb Bart's disease before ultrasound manifestation in affected pregnancies. Copyright © 2005 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | Globin | - |
dc.subject | Hb Bart's | - |
dc.subject | Noninvasive | - |
dc.subject.mesh | Antibodies, Monoclonal - Diagnostic Use | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Erythrocytes - Chemistry | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Blood - Chemistry | en_US |
dc.subject.mesh | Globins - Analysis - Immunology | en_US |
dc.subject.mesh | Hemoglobins, Abnormal - Analysis - Immunology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydrops Fetalis - Blood - Diagnosis - Epidemiology - Etiology | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Trimester, First | en_US |
dc.subject.mesh | Pregnancy Trimester, Second | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.title | Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/pd.1096 | en_US |
dc.identifier.pmid | 15712347 | - |
dc.identifier.scopus | eid_2-s2.0-14744267781 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-14744267781&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 123 | en_US |
dc.identifier.epage | 128 | en_US |
dc.identifier.isi | WOS:000227342300004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lau, ET=36006491400 | en_US |
dc.identifier.scopusauthorid | Kwok, YK=8247106700 | en_US |
dc.identifier.scopusauthorid | Luo, HY=37116363100 | en_US |
dc.identifier.scopusauthorid | Leung, KY=8247106900 | en_US |
dc.identifier.scopusauthorid | Lee, CP=7410141601 | en_US |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_US |
dc.identifier.scopusauthorid | Chui, DHK=34568906600 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.issnl | 0197-3851 | - |