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Article: Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

TitleLack of evidence for a major gene in the mendelian transmission of BMI in Chinese
Authors
Liu, PYLi, YMLi, MXMalkin, IQin, YJChen, XDLiu, YJDeng, HW
KeywordsBmi
Chinese Population
Familial Correlation
Major Genes
Segregation Analysis
Issue Date2004
PublisherNorth American Association for the Study of Obesity. The Journal's web site is located at http://www.obesityresearch.org
Citation
Obesity Research, 2004, v. 12 n. 12, p. 1967-1973 How to Cite?
DOI: http://dx.doi.org/10.1038/oby.2004.247
AbstractObjectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h 2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample. Copyright © 2004 NAASO.
Persistent Identifierhttp://hdl.handle.net/10722/181195
ISSN
1071-7323
ISI Accession Number ID
WOS:000226678700010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLiu, PYen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorMalkin, Ien_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorChen, XDen_US
dc.contributor.authorLiu, YJen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:41Z-
dc.date.available2013-02-21T02:02:41Z-
dc.date.issued2004en_US
dc.identifier.citationObesity Research, 2004, v. 12 n. 12, p. 1967-1973en_US
dc.identifier.issn1071-7323en_US
dc.identifier.urihttp://hdl.handle.net/10722/181195-
dc.description.abstractObjectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h 2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample. Copyright © 2004 NAASO.en_US
dc.languageengen_US
dc.publisherNorth American Association for the Study of Obesity. The Journal's web site is located at http://www.obesityresearch.orgen_US
dc.relation.ispartofObesity Researchen_US
dc.subjectBmien_US
dc.subjectChinese Populationen_US
dc.subjectFamilial Correlationen_US
dc.subjectMajor Genesen_US
dc.subjectSegregation Analysisen_US
dc.titleLack of evidence for a major gene in the mendelian transmission of BMI in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/oby.2004.247en_US
dc.identifier.pmid15687398-
dc.identifier.scopuseid_2-s2.0-18944394244en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18944394244&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue12en_US
dc.identifier.spage1967en_US
dc.identifier.epage1973en_US
dc.identifier.isiWOS:000226678700010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridLi, YM=7502098054en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridMalkin, I=6601954364en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridChen, XD=35487111000en_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US
dc.identifier.issnl1071-7323-

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