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- Publisher Website: 10.1155/2011/525497
- Scopus: eid_2-s2.0-78349268757
- PMID: 20936122
- WOS: WOS:000283225100001
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Article: Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules
Title | Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules |
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Authors | |
Issue Date | 2011 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html |
Citation | Journal Of Biomedicine And Biotechnology, 2011, v. 2011 How to Cite? |
Abstract | Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small molecules that characterize the metabolic pathways of biological systems. The study of metabolism at a global level has the potential to contribute significantly to biomedical research, clinical medical practice, as well as drug discovery. In this paper, we present the most up-to-date metabolite and metabolic pathway resources, and we summarize the statistical, and machine-learning tools used for the analysis of data from clinical metabolomics. Through specific applications on cancer, diabetes, neurological and other diseases, we demonstrate how these tools can facilitate diagnosis and identification of potential biomarkers for use within disease diagnosis. Additionally, we discuss the increasing importance of the integration of metabolomics data in drug discovery. On a case-study based on the Human Metabolome Database (HMDB) and the Chinese Natural Product Database (CNPD), we demonstrate the close relatedness of the two data sets of compounds, and we further illustrate how structural similarity with human metabolites could assist in the design of novel pharmaceuticals and the elucidation of the molecular mechanisms of medicinal plants. Copyright © 2011 Irene Kouskoumvekaki and Gianni Panagiotou. |
Persistent Identifier | http://hdl.handle.net/10722/181259 |
ISSN | 2014 Impact Factor: 3.169 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kouskoumvekaki, I | en_US |
dc.contributor.author | Panagiotou, G | en_US |
dc.date.accessioned | 2013-02-21T02:03:33Z | - |
dc.date.available | 2013-02-21T02:03:33Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Journal Of Biomedicine And Biotechnology, 2011, v. 2011 | en_US |
dc.identifier.issn | 1110-7243 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/181259 | - |
dc.description.abstract | Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small molecules that characterize the metabolic pathways of biological systems. The study of metabolism at a global level has the potential to contribute significantly to biomedical research, clinical medical practice, as well as drug discovery. In this paper, we present the most up-to-date metabolite and metabolic pathway resources, and we summarize the statistical, and machine-learning tools used for the analysis of data from clinical metabolomics. Through specific applications on cancer, diabetes, neurological and other diseases, we demonstrate how these tools can facilitate diagnosis and identification of potential biomarkers for use within disease diagnosis. Additionally, we discuss the increasing importance of the integration of metabolomics data in drug discovery. On a case-study based on the Human Metabolome Database (HMDB) and the Chinese Natural Product Database (CNPD), we demonstrate the close relatedness of the two data sets of compounds, and we further illustrate how structural similarity with human metabolites could assist in the design of novel pharmaceuticals and the elucidation of the molecular mechanisms of medicinal plants. Copyright © 2011 Irene Kouskoumvekaki and Gianni Panagiotou. | en_US |
dc.language | eng | en_US |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html | en_US |
dc.relation.ispartof | Journal of Biomedicine and Biotechnology | en_US |
dc.subject.mesh | Biological Markers - Metabolism | en_US |
dc.subject.mesh | Databases, Factual | en_US |
dc.subject.mesh | Drug Discovery | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Metabolomics | en_US |
dc.title | Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules | en_US |
dc.type | Article | en_US |
dc.identifier.email | Panagiotou, G: gipa@hku.hk | en_US |
dc.identifier.authority | Panagiotou, G=rp01725 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1155/2011/525497 | en_US |
dc.identifier.pmid | 20936122 | en_US |
dc.identifier.scopus | eid_2-s2.0-78349268757 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78349268757&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 2011 | en_US |
dc.identifier.isi | WOS:000283225100001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kouskoumvekaki, I=6602787035 | en_US |
dc.identifier.scopusauthorid | Panagiotou, G=8566179700 | en_US |
dc.identifier.issnl | 1110-7243 | - |