File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The chemical interactome space between the human host and the genetically defined gut metabotypes

TitleThe chemical interactome space between the human host and the genetically defined gut metabotypes
Authors
Keywordsmicrobiome; metabolic network; drugs; protein interactions; diseases
Issue Date2013
Citation
Isme Journal, 2013, v. 7 n. 4, p. 730-742 How to Cite?
AbstractThe bacteria that colonize the gastrointestinal tracts of mammals represent a highly selected microbiome that has a profound influence on human physiology by shaping the host's metabolic and immune system activity. Despite the recent advances on the biological principles that underlie microbial symbiosis in the gut of mammals, mechanistic understanding of the contributions of the gut microbiome and how variations in the metabotypes are linked to the host health are obscure. Here, we mapped the entire metabolic potential of the gut microbiome based solely on metagenomics sequencing data derived from fecal samples of 124 Europeans (healthy, obese and with inflammatory bowel disease). Interestingly, three distinct clusters of individuals with high, medium and low metabolic potential were observed. By illustrating these results in the context of bacterial population, we concluded that the abundance of the Prevotella genera is a key factor indicating a low metabolic potential. These metagenome-based metabolic signatures were used to study the interaction networks between bacteria-specific metabolites and human proteins. We found that thirty-three such metabolites interact with disease-relevant protein complexes several of which are highly expressed in cells and tissues involved in the signaling and shaping of the adaptive immune system and associated with squamous cell carcinoma and bladder cancer. From this set of metabolites, eighteen are present in DrugBank providing evidence that we carry a natural pharmacy in our guts. Furthermore, we established connections between the systemic effects of non-antibiotic drugs and the gut microbiome of relevance to drug side effects and health-care solutions.
Persistent Identifierhttp://hdl.handle.net/10722/181268
ISSN
2023 Impact Factor: 10.8
2023 SCImago Journal Rankings: 3.692
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJacobsen, UPen_US
dc.contributor.authorNielsen, HBen_US
dc.contributor.authorHildebrand, Fen_US
dc.contributor.authorRaes, Jen_US
dc.contributor.authorSicheritzPonten, Ten_US
dc.contributor.authorKouskoumvekaki, Ien_US
dc.contributor.authorPanagiotou, Gen_US
dc.date.accessioned2013-02-21T02:03:37Z-
dc.date.available2013-02-21T02:03:37Z-
dc.date.issued2013en_US
dc.identifier.citationIsme Journal, 2013, v. 7 n. 4, p. 730-742en_US
dc.identifier.issn1751-7362en_US
dc.identifier.urihttp://hdl.handle.net/10722/181268-
dc.description.abstractThe bacteria that colonize the gastrointestinal tracts of mammals represent a highly selected microbiome that has a profound influence on human physiology by shaping the host's metabolic and immune system activity. Despite the recent advances on the biological principles that underlie microbial symbiosis in the gut of mammals, mechanistic understanding of the contributions of the gut microbiome and how variations in the metabotypes are linked to the host health are obscure. Here, we mapped the entire metabolic potential of the gut microbiome based solely on metagenomics sequencing data derived from fecal samples of 124 Europeans (healthy, obese and with inflammatory bowel disease). Interestingly, three distinct clusters of individuals with high, medium and low metabolic potential were observed. By illustrating these results in the context of bacterial population, we concluded that the abundance of the Prevotella genera is a key factor indicating a low metabolic potential. These metagenome-based metabolic signatures were used to study the interaction networks between bacteria-specific metabolites and human proteins. We found that thirty-three such metabolites interact with disease-relevant protein complexes several of which are highly expressed in cells and tissues involved in the signaling and shaping of the adaptive immune system and associated with squamous cell carcinoma and bladder cancer. From this set of metabolites, eighteen are present in DrugBank providing evidence that we carry a natural pharmacy in our guts. Furthermore, we established connections between the systemic effects of non-antibiotic drugs and the gut microbiome of relevance to drug side effects and health-care solutions.en_US
dc.languageengen_US
dc.relation.ispartofISME Journalen_US
dc.subjectmicrobiome; metabolic network; drugs; protein interactions; diseases-
dc.titleThe chemical interactome space between the human host and the genetically defined gut metabotypesen_US
dc.typeArticleen_US
dc.identifier.emailPanagiotou, G: gipa@hku.hken_US
dc.identifier.authorityPanagiotou, G=rp01725en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ismej.2012.141en_US
dc.identifier.pmid23178670-
dc.identifier.scopuseid_2-s2.0-84875371139en_US
dc.identifier.hkuros221463-
dc.identifier.isiWOS:000316727800005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJacobsen, UP=55498855900en_US
dc.identifier.scopusauthoridNielsen, HB=16146137400en_US
dc.identifier.scopusauthoridHildebrand, F=37026203600en_US
dc.identifier.scopusauthoridRaes, J=8602126700en_US
dc.identifier.scopusauthoridSicheritzPonten, T=6602257307en_US
dc.identifier.scopusauthoridKouskoumvekaki, I=6602787035en_US
dc.identifier.scopusauthoridPanagiotou, G=8566179700en_US
dc.identifier.issnl1751-7362-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats