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Article: Micro-scale stiffness change of cornea tissues suffered from elevated intraocular pressure investigated by nanoindentation

TitleMicro-scale stiffness change of cornea tissues suffered from elevated intraocular pressure investigated by nanoindentation
Authors
Wu, KSLi, SYLo, ACYNgan, AHWWong, DSHSo, KFEllis-Behnke, RGTang, B
KeywordsCornea
Glaucoma
Nanoindentation
Issue Date2013
PublisherTaylor & Francis. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1539445X.asp
Citation
Soft Materials, 2013, v. 11, p. 244-253 How to Cite?
DOI: http://dx.doi.org/10.1080/1539445X.2011.622030
AbstractElevated intraocular pressure (IOP) is the main risk factor of glaucoma. In this study, an elevated IOP was introduced into the right eye balls of Sprague-Dawley rats, while their left eye balls were kept at a normal state. Nanoindentation showed that the elastic modulus of normal corneas was 2.75-3.33 MPa, whereas that of elevated IOP group was higher at 4.89-5.58 MPa. Scanning electron microscopy imaging suggested that the collagen fibrils subjected to the elevated IOP became thinner and with random directionality. It is believed the observed increase in elastic modulus should due to the strain-stiffening effects of collagen fibrils.
Persistent Identifierhttp://hdl.handle.net/10722/181845
ISSN
1539-445X
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.320
ISI Accession Number ID
WOS:000322306400002

 

DC FieldValueLanguage
dc.contributor.authorWu, KSen_US
dc.contributor.authorLi, SYen_US
dc.contributor.authorLo, ACYen_US
dc.contributor.authorNgan, AHWen_US
dc.contributor.authorWong, DSHen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorEllis-Behnke, RGen_US
dc.contributor.authorTang, Ben_US
dc.date.accessioned2013-03-19T04:02:47Z-
dc.date.available2013-03-19T04:02:47Z-
dc.date.issued2013en_US
dc.identifier.citationSoft Materials, 2013, v. 11, p. 244-253en_US
dc.identifier.issn1539-445X-
dc.identifier.urihttp://hdl.handle.net/10722/181845-
dc.description.abstractElevated intraocular pressure (IOP) is the main risk factor of glaucoma. In this study, an elevated IOP was introduced into the right eye balls of Sprague-Dawley rats, while their left eye balls were kept at a normal state. Nanoindentation showed that the elastic modulus of normal corneas was 2.75-3.33 MPa, whereas that of elevated IOP group was higher at 4.89-5.58 MPa. Scanning electron microscopy imaging suggested that the collagen fibrils subjected to the elevated IOP became thinner and with random directionality. It is believed the observed increase in elastic modulus should due to the strain-stiffening effects of collagen fibrils.-
dc.languageengen_US
dc.publisherTaylor & Francis. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1539445X.aspen_US
dc.relation.ispartofSoft Materialsen_US
dc.rightsPREPRINT This is a preprint of an article whose final and definitive form has been published in the [JOURNAL TITLE] [year of publication] [copyright Taylor & Francis]; [JOURNAL TITLE] is available online at: http://www.informaworld.com/smpp/ with the open URL of your article POSTPRINT ‘This is an electronic version of an article published in [include the complete citation information for the final version of the article as published in the print edition of the journal]. [JOURNAL TITLE] is available online at: http://www.informaworld.com/smpp/ with the open URL of your article.en_US
dc.subjectCornea-
dc.subjectGlaucoma-
dc.subjectNanoindentation-
dc.titleMicro-scale stiffness change of cornea tissues suffered from elevated intraocular pressure investigated by nanoindentationen_US
dc.typeArticleen_US
dc.identifier.emailLi, SY: sukyeeli@hku.hken_US
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_US
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hken_US
dc.identifier.emailWong, DSH: shdwong@hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailEllis-Behnke, RG: rutledge@hkucc.hku.hken_US
dc.identifier.emailTang, B: tangbinsci@gmail.com-
dc.identifier.authorityLo, ACY=rp00425en_US
dc.identifier.authorityNgan, AHW=rp00225en_US
dc.identifier.authorityWong, DSH=rp00516en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityEllis-Behnke, RG=rp00252en_US
dc.identifier.authorityTang, B=rp00081-
dc.identifier.doi10.1080/1539445X.2011.622030-
dc.identifier.scopuseid_2-s2.0-84874435444-
dc.identifier.hkuros213633en_US
dc.identifier.volume11en_US
dc.identifier.spage244en_US
dc.identifier.epage253en_US
dc.identifier.eissn1539-4468-
dc.identifier.isiWOS:000322306400002-
dc.identifier.issnl1539-445X-

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