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Article: Direct retino-raphe projection alters serotonergic tone and affective behavior

TitleDirect retino-raphe projection alters serotonergic tone and affective behavior
Authors
Keywordsaffective visual information
depression
dorsal raphe nucleus
retinal ganglion cell
SSRI
Issue Date2013
PublisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org
Citation
Neuropsychopharmacology, 2013, v. 38 n. 7, p. 1163-1175 How to Cite?
AbstractLight is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.
Persistent Identifierhttp://hdl.handle.net/10722/184458
ISSN
2023 Impact Factor: 6.6
2023 SCImago Journal Rankings: 2.743
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRen, Cen_US
dc.contributor.authorLuan, Len_US
dc.contributor.authorLau, WMen_US
dc.contributor.authorHuang, Xen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorGao, Jen_US
dc.contributor.authorPickard, GEen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorPu, Men_US
dc.date.accessioned2013-07-15T09:47:28Z-
dc.date.available2013-07-15T09:47:28Z-
dc.date.issued2013en_US
dc.identifier.citationNeuropsychopharmacology, 2013, v. 38 n. 7, p. 1163-1175en_US
dc.identifier.issn0893-133X-
dc.identifier.urihttp://hdl.handle.net/10722/184458-
dc.description.abstractLight is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.-
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org-
dc.relation.ispartofNeuropsychopharmacologyen_US
dc.subjectaffective visual information-
dc.subjectdepression-
dc.subjectdorsal raphe nucleus-
dc.subjectretinal ganglion cell-
dc.subjectSSRI-
dc.titleDirect retino-raphe projection alters serotonergic tone and affective behavioren_US
dc.typeArticleen_US
dc.identifier.emailLau, WM: bwmlau@hku.hken_US
dc.identifier.emailYang, J: jianyang@hkucc.hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/npp.2013.35-
dc.identifier.pmid23370156-
dc.identifier.pmcidPMC3656380-
dc.identifier.scopuseid_2-s2.0-84878563273-
dc.identifier.hkuros215680en_US
dc.identifier.volume38en_US
dc.identifier.issue7-
dc.identifier.spage1163en_US
dc.identifier.epage1175en_US
dc.identifier.isiWOS:000319120000003-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0893-133X-

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