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- Publisher Website: 10.1016/j.bbrc.2013.06.021
- Scopus: eid_2-s2.0-84880041768
- PMID: 23791740
- WOS: WOS:000322415400025
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Article: Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma
Title | Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma |
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Authors | |
Keywords | CENPF G2/M transition HCC Prognosis factor |
Issue Date | 2013 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical and Biophysical Research Communications, 2013, v. 436 n. 4, p. 711-718 How to Cite? |
Abstract | Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and functional role of CENPF in hepatocellular carcinoma (HCC). We found CENPF was frequently overexpressed in HCC as compared with non-tumor tissue. Up-regulated CENPF expression in HCC was positively correlated with serum AFP, venous invasion, advanced differentiation stage and a shorter overall survival. Cox regression analysis found that overexpression of CENPF was an independent prognosis factor in HCC. Functional studies found that silencing CENPF could decrease the ability of the cells to proliferate, form colonies and induce tumor formation in nude mice. Silencing CENPF also resulted in the cell cycle arrest at G2/M checkpoint by down-regulating cell cycle proteins cdc2 and cyclin B1. Our data suggest that CENPF is frequently overexpressed in HCC and plays a critical role in driving HCC tumorigenesis. © 2013 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/184489 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Dai, YD | - |
dc.contributor.author | Liu, LL | - |
dc.contributor.author | Zeng, TT | - |
dc.contributor.author | Zhu, YH | - |
dc.contributor.author | Li, JC | - |
dc.contributor.author | Chen, L | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Yuan, YF | - |
dc.contributor.author | Ma, SKY | - |
dc.contributor.author | Guan, X | - |
dc.date.accessioned | 2013-07-15T09:50:25Z | - |
dc.date.available | 2013-07-15T09:50:25Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2013, v. 436 n. 4, p. 711-718 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10722/184489 | - |
dc.description.abstract | Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and functional role of CENPF in hepatocellular carcinoma (HCC). We found CENPF was frequently overexpressed in HCC as compared with non-tumor tissue. Up-regulated CENPF expression in HCC was positively correlated with serum AFP, venous invasion, advanced differentiation stage and a shorter overall survival. Cox regression analysis found that overexpression of CENPF was an independent prognosis factor in HCC. Functional studies found that silencing CENPF could decrease the ability of the cells to proliferate, form colonies and induce tumor formation in nude mice. Silencing CENPF also resulted in the cell cycle arrest at G2/M checkpoint by down-regulating cell cycle proteins cdc2 and cyclin B1. Our data suggest that CENPF is frequently overexpressed in HCC and plays a critical role in driving HCC tumorigenesis. © 2013 Elsevier Inc. | - |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject | CENPF | - |
dc.subject | G2/M transition | - |
dc.subject | HCC | - |
dc.subject | Prognosis factor | - |
dc.title | Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Chen, L: pollyllc@hku.hk | - |
dc.identifier.email | Ma, SKY: stefma@hku.hk | - |
dc.identifier.email | Guan, X: xyguan@hkucc.hku.hk | - |
dc.identifier.authority | Ma, SKY=rp00506 | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.06.021 | - |
dc.identifier.pmid | 23791740 | - |
dc.identifier.scopus | eid_2-s2.0-84880041768 | - |
dc.identifier.hkuros | 215086 | - |
dc.identifier.volume | 436 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 711 | - |
dc.identifier.epage | 718 | - |
dc.identifier.isi | WOS:000322415400025 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0006-291X | - |